肠道微生物群对自身免疫性疾病中B细胞的影响。
The influence of the gut microbiota on B cells in autoimmune diseases.
作者信息
He Lun, Li Xin, Jiang Shan, Ou Yanhua, Wang Shanshan, Shi Na, Yang Zhongshan, Yuan Jia-Li, Silverman Gregg, Niu Haitao
机构信息
Key Laboratory of Viral Pathogenesis & Infection Prevention and Control (Jinan University), Ministry of Education; Guangzhou Key Laboratory for Germ-free Animals and Microbiota Application, School of Medicine, Jinan University, Guangzhou, 510632, China.
Yunnan Provincial Key Laboratory of Molecular Biology for Sinomedicine, Yunnan University of Chinese Medicine, Kunming, Yunnan, 650500, China.
出版信息
Mol Med. 2025 Apr 22;31(1):149. doi: 10.1186/s10020-025-01195-5.
Mounting evidence shows that gut microbiota communities and the human immune system coexist and influence each other, and there are a number of reports of a correlation between specific changes in gut microbiota and the occurrence of autoimmune diseases. B lymphocytes play a central role in the regulation of both gut microbiota communities and in autoimmune diseases. Here, we summarize evidence of the influence of gut microbiota-B cell pathways on autoimmune diseases and how B cells regulate microorganisms, which provides mechanistic insights with relevance for identification of potential therapeutic targets and related fields.
越来越多的证据表明，肠道微生物群与人类免疫系统共存并相互影响，而且有许多关于肠道微生物群的特定变化与自身免疫性疾病发生之间相关性的报道。B淋巴细胞在肠道微生物群的调节以及自身免疫性疾病中都发挥着核心作用。在此，我们总结了肠道微生物群-B细胞通路对自身免疫性疾病影响的证据，以及B细胞如何调节微生物，这为确定潜在治疗靶点及相关领域提供了机制性见解。
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