Liu Xiaona, Lu Xiuhai, Zheng Juanjuan, Liu Shujuan, Li Man
Clinical Laboratory, Jinan Mingshui Eye Hospital, Longquan Road 5601, Zhangqiu District, Jinan, China.
Clinical Laboratory, Shandong Eye Hospital, Jingsi Road 372, Huaiyin District, Jinan, China.
BMC Ophthalmol. 2025 Apr 22;25(1):230. doi: 10.1186/s12886-025-04064-1.
Phaeoacremonium is typically found in the environment and can cause diseases in woody plants. It is rarely responsible for infections in humans.
In this report, we present a case of corneal infection caused by Phaeoacremonium iranianum. Caused a fan-shaped grayish-white ulcer measuring approximately 4 mm×3 mm inferior nasal cornea. The ulcer appeared relatively dry, with noticeable swelling and cloudiness in the surrounding cornea. The visual acuity after infection was 0.25. We started an aggressive antifungal therapy. Our antifungal susceptibility testing revealed the Minimum Inhibitory Concentration of anifengin was 4 µg/ml, Micafengin and carpofungin exceeding 8 µg/ml, fluorocytosine was 32 µg/ml, posaconazole was 1 µg/ml, voriconazole was 0.5 µg/ml, itraconazole was 2 µg/ml, fluconazole was 64 µg/ml, and amphotericin was 0.05 µg/ml. The patient underwent keratectomy combined with antifungal therapy. A month later, the conjunctiva of the right eye was congested, and a 4*4 mm corneal opacity was visible inferior nasal cornea, with local obvious thinning and a little keratic precipitates on the inner skin, and the infection has been controlled.
We detail the progression and treatment of this infection to contribute to the clinical understanding and management of such cases.
拟青霉通常存在于环境中，可引起木本植物疾病。它很少导致人类感染。
在本报告中，我们呈现了一例由伊朗拟青霉引起的角膜感染病例。在角膜鼻下象限导致了一个约4毫米×3毫米的扇形灰白色溃疡。溃疡看起来相对干燥，周围角膜有明显肿胀和混浊。感染后的视力为0.25。我们开始了积极的抗真菌治疗。我们的抗真菌药敏试验显示，阿尼芬净的最低抑菌浓度为4微克/毫升，米卡芬净和卡泊芬净超过8微克/毫升，氟胞嘧啶为32微克/毫升，泊沙康唑为1微克/毫升，伏立康唑为0.5微克/毫升，伊曲康唑为2微克/毫升，氟康唑为64微克/毫升，两性霉素为0.05微克/毫升。患者接受了角膜切除术并联合抗真菌治疗。一个月后，右眼结膜充血，角膜鼻下象限可见一个4×4毫米的角膜混浊，局部明显变薄，内皮有少许角膜后沉着物，感染已得到控制。
我们详细描述了这种感染的进展和治疗情况，以促进对此类病例的临床认识和管理。
