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SARS-CoV-2引发成人斯蒂尔病的长期健康后果

Long-Term Health Consequences of SARS-CoV-2- Trigger for Still Disease in Adults.

作者信息

Zavidić Tina, Dejhalla Ema, Lesac Brizić Ana, Popović Branislava

机构信息

University of Rijeka and Istrian Health Centers, Pazin, Croatia.

Medical Centre for Occupational Health Rijeka, Rijeka, Croatia.

出版信息

ACR Open Rheumatol. 2025 Apr;7(4):e70042. doi: 10.1002/acr2.70042.

Abstract

Still disease is a rare inflammatory disorder often triggered by infections or malignancies, with SARS-CoV-2 as a possible factor. This paper explores a 56-year-old patient who developed adult-onset Still disease after COVID-19. Symptoms included fever, arthralgia, rash, hepatomegaly, and joint swelling. Diagnosis followed Yamaguchi criteria and treatment with glucocorticoids and immunosuppressants led to recovery. The paper discusses similarities between Still disease and severe COVID-19 that suggest shared inflammatory mechanisms, particularly IL-1 activation. Early diagnosis and treatment are vital. Further research is needed to clarify the link between Still disease and SARS-CoV-2 and improve treatment strategies.

摘要

斯蒂尔病是一种罕见的炎症性疾病,通常由感染或恶性肿瘤引发,严重急性呼吸综合征冠状病毒2(SARS-CoV-2)也可能是诱发因素。本文探讨了一名56岁的患者,其在感染新型冠状病毒肺炎(COVID-19)后患上成人斯蒂尔病。症状包括发热、关节痛、皮疹、肝肿大和关节肿胀。诊断依据山口标准,使用糖皮质激素和免疫抑制剂进行治疗后患者康复。本文讨论了斯蒂尔病与重症COVID-19之间的相似之处,这些相似之处表明两者存在共同的炎症机制,尤其是白细胞介素-1(IL-1)的激活。早期诊断和治疗至关重要。需要进一步研究以阐明斯蒂尔病与SARS-CoV-2之间的联系并改进治疗策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a32b/12014914/3acba1ca4b7f/ACR2-7-e70042-g001.jpg

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