Induction of Chaperone Synthesis in Human Neuronal Cells Blocks Oxidative Stress-Induced Aging.

Oxidative stress accompanies many pathologies that are characterized by neuronal degradation leading to a deterioration of the disease. The main causes are the disruption of protein homeostasis and activation of irreversible processes of cell cycle disruption and deterioration of cellular physiology, leading to senescence. In this paper, we propose a new approach to combating senescence caused by oxidative stress. This approach is based on the use of a low-molecular inducer of chaperone synthesis, one of the cell protective systems regulating proteostasis and apoptosis. We present data demonstrating the ability of the pyrrolylazine derivative PQ-29 to induce chaperone accumulation in human neuronal cells and prevent oxidative stress-induced aging.