Kupriyanov S V, Kirilenko K M, Starkov D N
Tomsk State University, Laboratory of Evolutionary Cytogenetics, Tomsk, 634050 Russian Federation.
Acta Naturae. 2025 Jan-Mar;17(1):11-19. doi: 10.32607/actanaturae.27549.
Immunoregulatory enzymes, which function both as biological catalysts and regulatory elements, play a crucial role in controlling immune responses. Dysfunction of these proteins can contribute to various pathological conditions, such as the suppression of antitumor immunity or impairment of anti-infectious immune responses. This review discusses the most extensively studied immunoregulatory enzymes, including indoleamine 2,3-dioxygenase 1, arginase 1, inducible nitric oxide synthase, glyceraldehyde-3-phosphate dehydrogenase, and ectonucleoside triphosphate diphosphohydrolase 1. Their classification is provided, along with an analysis of the distinctive characteristics inherent to this group of enzymes. Additionally, new directions for the medical application of immunoregulatory enzymes are explored.
免疫调节酶既作为生物催化剂又作为调节元件发挥作用，在控制免疫反应中起着关键作用。这些蛋白质的功能障碍可导致各种病理状况，如抗肿瘤免疫抑制或抗感染免疫反应受损。本综述讨论了研究最广泛的免疫调节酶，包括吲哚胺2,3-双加氧酶1、精氨酸酶1、诱导型一氧化氮合酶、甘油醛-3-磷酸脱氢酶和外切核苷酸三磷酸二磷酸水解酶1。提供了它们的分类，并分析了这组酶固有的独特特征。此外，还探索了免疫调节酶医学应用的新方向。
