Liao Yayun, Zhou Kejian, Lin Baoquan, Deng Shan, Qin Lu, Weng Baohui, Yang Hong, Pan Liya
Department of Neurology, The Fourth Affiliated Hospital of Guangxi Medical University, Liuzhou, China.
Front Neurol. 2025 Apr 8;16:1490760. doi: 10.3389/fneur.2025.1490760. eCollection 2025.
Selenium (Se) is essential for many nervous system functions including memory, cognition and coordination, which has also been linked to a variety of neurological disorders, such as epilepsy, Alzheimer's disease (AD) and Parkinson's disease (PD). Serum neurofilament light chain (sNfL) is a biomarker of neurologic diseases. Studies on the relationship between blood Se and sNfL are limited.
The National Health and Nutrition Examination Survey (NHANES) 2013-2014 data were employed to perform multivariate linear regression analysis and smooth curve fitting in order to investigate the relationship between blood Se and sNfL. Utilizing subgroup analyses and interaction tests, the stability of this relationship between populations was evaluated.
sNfL and blood Se had an inverse relationship in 1,036 individuals who were older than 20. According to the fully adjusted model, the sNfL decreased by 54.75 pg./mL for every unit increase in log blood Se [ = -54.75, 95% CI (-75.36, -34.14)]. The sNfL of individuals in the highest blood Se quartile decreased by 3.4 pg./mL in comparison to those in the lowest quartile [ = -3.40, 95% CI (-6.47, -0.32)]. This inverse association was more significant in those who were younger than 60 years old, male, normal weight, had a history of smoking and drinking.
Blood Se is inversely associated with sNfL in American adults. Our findings indicate that blood Se may have a potential protective effect against neuronal damage.
硒（Se）对包括记忆、认知和协调在内的许多神经系统功能至关重要，其还与多种神经系统疾病有关，如癫痫、阿尔茨海默病（AD）和帕金森病（PD）。血清神经丝轻链（sNfL）是神经系统疾病的生物标志物。关于血硒与sNfL之间关系的研究有限。
采用2013 - 2014年美国国家健康与营养检查调查（NHANES）数据进行多元线性回归分析和平滑曲线拟合，以研究血硒与sNfL之间的关系。利用亚组分析和交互作用检验，评估不同人群中这种关系的稳定性。
在1036名年龄大于20岁的个体中，sNfL与血硒呈负相关。根据完全调整模型，血硒对数每增加一个单位，sNfL降低54.75 pg./mL [β = -54.75，95%可信区间（-75.36，-34.14）]。血硒处于最高四分位数的个体的sNfL比最低四分位数的个体降低了3.4 pg./mL [β = -3.40，95%可信区间（-6.47，-0.32）]。这种负相关在年龄小于60岁、男性、体重正常、有吸烟和饮酒史的人群中更为显著。
美国成年人的血硒与sNfL呈负相关。我们的研究结果表明，血硒可能对神经元损伤具有潜在的保护作用。
