Qi Ling, Yi Xue-Cai, Li Chen, Li Yan
Department of Anesthesiology, Jinan Maternity and Child Care Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, People's Republic of China.
Department of Anesthesiology, Yantai Hospital of Traditional Chinese Medicine, YanTai, People's Republic of China.
Int J Gen Med. 2025 Apr 18;18:2197-2206. doi: 10.2147/IJGM.S509897. eCollection 2025.
To analyze the effects of sevoflurane combined with propofol anesthesia on hemodynamics, stress response, pain, and cognitive function in elderly patients undergoing radical surgery for malignant tumors.
A retrospective analysis was performed on 100 elderly patients undergoing radical surgery for malignant tumors at our hospital from February 2023 to June 2024. The patients were divided into two groups based on anesthesia method: the control group (n=50, propofol anesthesia) and the observation group (n=50, sevoflurane combined with propofol anesthesia). Anesthesia parameters, stress response indicators (norepinephrine, epinephrine, renin), hemodynamic indicators (heart rate, mean arterial pressure, systolic and diastolic blood pressure), pain levels (visual analog scale), cognitive function (Mini-Mental State Examination), and adverse reactions were compared between the two groups.
The observation group showed significantly shorter times to loss of consciousness, awakening, and extubation compared to the control group (P < 0.05). Stress markers (norepinephrine, epinephrine, renin) were less elevated in the observation group compared to the control group five minutes after extubation (P < 0.05). Hemodynamic parameters (heart rate, mean arterial pressure, systolic and diastolic blood pressure) were more stable in the observation group (P < 0.05). The visual analog scale (VAS) scores were lower in the observation group at 12 and 24 hours postoperatively compared to the control group (P < 0.05). Mini-Mental State Examination (MMSE) scores were significantly higher in the observation group at 4 and 8 hours postoperatively (P < 0.05). The incidence of adverse reactions was similar between the two groups (P > 0.05).
Sevoflurane combined with propofol anesthesia is more effective than propofol anesthesia alone in elderly patients undergoing radical surgery for malignant tumors. It better alleviates stress responses, maintains hemodynamic stability, improves postoperative pain and cognitive function, and does not increase the risk of adverse reactions.
分析七氟醚联合丙泊酚麻醉对老年恶性肿瘤根治手术患者血流动力学、应激反应、疼痛及认知功能的影响。
对2023年2月至2024年6月在我院接受恶性肿瘤根治手术的100例老年患者进行回顾性分析。根据麻醉方法将患者分为两组：对照组（n = 50，丙泊酚麻醉）和观察组（n = 50，七氟醚联合丙泊酚麻醉）。比较两组的麻醉参数、应激反应指标（去甲肾上腺素、肾上腺素、肾素）、血流动力学指标（心率、平均动脉压、收缩压和舒张压）、疼痛程度（视觉模拟评分）、认知功能（简易精神状态检查表）及不良反应。
与对照组相比，观察组的意识消失时间、苏醒时间和拔管时间明显缩短（P < 0.05）。拔管后5分钟，观察组的应激标志物（去甲肾上腺素、肾上腺素、肾素）升高幅度低于对照组（P < 0.05）。观察组的血流动力学参数（心率、平均动脉压、收缩压和舒张压）更稳定（P < 0.05）。与对照组相比，观察组术后12小时和24小时的视觉模拟评分（VAS）更低（P < 0.05）。观察组术后4小时和8小时的简易精神状态检查表（MMSE）评分明显更高（P < 0.05）。两组不良反应发生率相似（P > 0.05）。
对于接受恶性肿瘤根治手术的老年患者，七氟醚联合丙泊酚麻醉比单纯丙泊酚麻醉更有效。它能更好地减轻应激反应，维持血流动力学稳定，改善术后疼痛和认知功能，且不增加不良反应风险。
