丙泊酚与七氟醚麻醉下胶质瘤手术患者的临床观察：一项回顾性研究
Clinical Observation of Patients Undergoing Glioma Surgery under Propofol and Sevoflurane Anesthesia: A Retrospective Study.
作者信息
Fang Junbiao, Wang Hongfa, Zhang Weihua, Yang Kaichuang, Wang Weiyu
机构信息
Department of Anesthesiology, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, China.
Department of Neurosurgery, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, China.
出版信息
J Oncol. 2022 Jun 8;2022:4516537. doi: 10.1155/2022/4516537. eCollection 2022.
OBJECTIVE
To observe the effects of propofol and sevoflurane anesthesia on patients undergoing glioma surgery.
METHODS
192 patients with gliomas treated in our hospital from January 2016 to January 2021 were selected. All patients were randomly divided into observation group and control group. The observation group was given sevoflurane and the control group was given propofol. The clinical effects of the two groups were observed.
RESULTS
Comparison of clinical indexes related to intraoperative conditions between the two groups revealed that the time of anesthesia and extubation after operation in the observation group were shorter than those in the control group, and the difference was statistically significant ( < 0.05). The amount of intraoperative bleeding in the observation group was less than that in the control group, and the difference was statistically significant ( < 0.05). There was no significant difference in intracranial operation time, operation time, fluid volume, and urine volume between the two groups (P < 05). Comparing the recovery time of anesthesia between the two groups, the recovery time of orientation and the time of eye-opening in the observation group were significantly shorter than those in the control group ( < 0.05). Comparing the consciousness and cognitive function of the two groups, the OAAS score of the observation group after extubation, before leaving the operating room and 1 hour after extubation, was significantly higher than that of the control group ( < 0.05), and the MMSE score l h after extubation was significantly higher than that of the control group ( < 0.05). Comparing the incidence of postoperative complications between the two groups, the number of cases of restlessness, urinary infection, deep vein thrombosis, and hypertension in the observation group was lower than that in the control group, with statistical significance ( < 0.05).
CONCLUSION
The anesthesia time and extubation time of the sevoflurane anesthesia group were shorter than that of the propofol anesthesia group, and the orientation recovery time and eye-opening time were shortened. The OAAS score of the sevoflurane anesthesia group was higher than that of the propofol anesthesia group after extubation, before extubation, and 1 hour after extubation. The probability of postoperative complications in the sevoflurane anesthesia group was lower than that in the propofol anesthesia group. Sevoflurane anesthesia may be more suitable for surgical induction of glioma patients than propofol anesthesia.
目的
观察丙泊酚和七氟醚麻醉对胶质瘤手术患者的影响。
方法
选取2016年1月至2021年1月在我院治疗的192例胶质瘤患者。所有患者随机分为观察组和对照组。观察组给予七氟醚，对照组给予丙泊酚。观察两组的临床效果。
结果
两组术中相关临床指标比较显示，观察组术后麻醉时间和拔管时间短于对照组，差异有统计学意义（<0.05）。观察组术中出血量少于对照组，差异有统计学意义（<0.05）。两组颅内手术时间、手术时间、液体量和尿量比较差异无统计学意义（P<0.05）。比较两组麻醉恢复时间，观察组定向力恢复时间和睁眼时间明显短于对照组（<0.05）。比较两组意识和认知功能，观察组拔管后、出手术室前及拔管后1小时的OAAS评分明显高于对照组（<0.05），拔管后1小时的MMSE评分明显高于对照组（<0.05）。比较两组术后并发症发生率，观察组躁动、泌尿系感染、深静脉血栓形成和高血压病例数低于对照组，差异有统计学意义（<0.05）。
结论
七氟醚麻醉组的麻醉时间和拔管时间短于丙泊酚麻醉组，定向力恢复时间和睁眼时间缩短。七氟醚麻醉组拔管后、拔管前及拔管后1小时的OAAS评分高于丙泊酚麻醉组。七氟醚麻醉组术后并发症发生率低于丙泊酚麻醉组。七氟醚麻醉可能比丙泊酚麻醉更适合胶质瘤患者的手术诱导。
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