Suri Arjan, Satani Sahaj, Dobrovolny Hana M
Department of Physics & Astronomy, Texas Christian University, Fort Worth, TX 76129, USA.
Epidemiologia (Basel). 2025 Apr 1;6(2):16. doi: 10.3390/epidemiologia6020016.
Respiratory syncytial virus (RSV) is a common respiratory virus that can cause serious illness in infants and the elderly. Vaccines for RSV have recently been introduced and have been shown to reduce the severity of the disease. However, there has been limited examination of how viral dynamics differ between vaccinated and unvaccinated individuals. Here, we use data from the MVA-BN-RSV Phase II vaccine study to quantify the dynamical differences between vaccinated and unvaccinated patients challenged with RSV. We use an ordinary differential equation model of within host viral dynamics to fit viral load data. We find statistically significant differences in viral clearance rate and basic reproduction number. We also find that vaccinated patients experience a higher response variance than the placebo group. While the differences in viral clearance and basic reproduction number are promising, the high variability in response to the vaccine could leave many vaccinated patients without adequate protection.
呼吸道合胞病毒（RSV）是一种常见的呼吸道病毒，可导致婴儿和老年人患上严重疾病。RSV疫苗最近已投入使用，并已证明可降低疾病的严重程度。然而，关于接种疫苗和未接种疫苗个体之间病毒动态如何不同的研究有限。在此，我们使用MVA-BN-RSV II期疫苗研究的数据来量化接种疫苗和未接种疫苗的患者在受到RSV攻击后的动态差异。我们使用宿主内病毒动态的常微分方程模型来拟合病毒载量数据。我们发现病毒清除率和基本再生数存在统计学上的显著差异。我们还发现，接种疫苗的患者比安慰剂组经历更高的反应方差。虽然病毒清除和基本再生数的差异很有前景，但对疫苗反应的高变异性可能会使许多接种疫苗的患者得不到充分保护。
