Peachey J E, Rogers B, Brien J F
Psychopharmacology (Berl). 1977 Jan 31;51(2):137-40. doi: 10.1007/BF00431729.
The behavioural effects induced in mice by the chronic administration of (+)-methamphetamine (MA) and (+)-amphetamine (A) at three dosages were studied under identical research conditions. The results indicated that MA exerted greater central excitation than A. At the dosage 0.64 mg/kg quiescence was decreased and activity increased more by MA than A. Hyperactivity induced at the 2.5 mg/kg dosage was sustained over a longer time period with MA. Frenzied self-tearing emerged with repeated drug administration at the 10 mg/kg dose in more MA-treated than A-treated animals.
在相同的研究条件下，研究了三种剂量的（+）-甲基苯丙胺（MA）和（+）-苯丙胺（A）长期给药对小鼠行为的影响。结果表明，MA比A具有更强的中枢兴奋作用。在剂量为0.64mg/kg时，MA比A更能降低静息状态并增加活动。在2.5mg/kg剂量下，MA诱导的多动持续时间更长。在10mg/kg剂量下，重复给药后，接受MA治疗的动物比接受A治疗的动物出现更多的疯狂自伤行为。
