Wood W G, Schreiber H L, Villescas R, Carlson R H
Psychopharmacology (Berl). 1977 Jan 31;51(2):165-8. doi: 10.1007/BF00431734.
The degree of habituation or adaptation an animal has experienced prior to the administration of methylphenidate was found to be more crucial in determining the animal's response to the drug than chronic drug administration alone. Rats allowed to adapt in a Y-maze for 24 days showed less methylphenidate-induced activity than animals receiving chronic administration of saline or methylphenidate but no adaptation, when animals were injected with the drug and tested in the Y-maze on Day 25. Animals also were shown to develop tolerance to the methylphenidate-induced activity.
研究发现，动物在服用哌醋甲酯之前所经历的习惯化或适应程度，在决定动物对该药物的反应方面，比单纯长期给药更为关键。在Y型迷宫中适应24天的大鼠，与接受生理盐水或哌醋甲酯长期给药但未适应的动物相比，在第25天注射药物并在Y型迷宫中进行测试时，其哌醋甲酯诱导的活动较少。动物还表现出对哌醋甲酯诱导活动的耐受性。
