Wood W G
Psychopharmacology (Berl). 1977 Mar 23;52(1):67-72. doi: 10.1007/BF00426602.
The purpose of this study was to examine the relationship between the development of tolerance to ethanol and the hypothalamic-pituitary-adrenal cortex (H-P-AC) system by modifying the H-P-AC system through the use of a synthetic glucocorticoid, dexamethasone. Also this study determined whether repeated drug administration and environmental adaptation would facilitate development of tolerance. Rats injected daily with dexamethasone and ethanol showed an antagonism to the acute effects of ethanol and a higher rate of tolerance development to the depressant effect of ethanol than animals administered ethanol only. These results were discussed in relation to a possible stimulant effect of dexamethasone on behavior, an increase in the metabolism of ethanol, and a possible accumulation of dexamethasone in the brain, affecting an organism's response to ethanol. It also was shown that daily ethanol administration and adaptation to the testing environment facilitated the development of tolerance, compared to ethanol administration only.
本研究的目的是通过使用合成糖皮质激素地塞米松来改变下丘脑 - 垂体 - 肾上腺皮质（H - P - AC）系统，从而研究乙醇耐受性的发展与该系统之间的关系。此外，本研究还确定了重复给药和环境适应是否会促进耐受性的发展。每天注射地塞米松和乙醇的大鼠对乙醇的急性作用表现出拮抗作用，并且与仅给予乙醇的动物相比，对乙醇抑制作用的耐受性发展速率更高。针对地塞米松对行为可能的刺激作用、乙醇代谢增加以及地塞米松可能在大脑中的蓄积影响生物体对乙醇的反应，对这些结果进行了讨论。研究还表明，与仅给予乙醇相比，每日给予乙醇并适应测试环境促进了耐受性的发展。
