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礼来110140（盐酸氟西汀）后的颅内奖赏：血清素起抑制作用的证据

Intracranial reward after Lilly 110140 (fluoxetine HCl): evidence for an inhibitory role for serotonin.

作者信息

Katz R J, Carroll B J

出版信息

Psychopharmacology (Berl). 1977 Jan 31;51(2):189-93. doi: 10.1007/BF00431739.

DOI:10.1007/BF00431739
PMID:402672
Abstract

The 5-hydroxytryptamine (5-HT, serotonin) specific presynaptic reuptake inhibitor Lilly 110140 (fluoxetine hydroxhloride) was injected systemically in rats trained to bar-press for rewarding stimulation to the caudal portion of the medial forebrain bundle. Rates of self stimulation were reduced in proportion to drug dosage, and these reductions were partially reversible by methysergide. These findings are consistent with previous reports suggesting an inhibitory role for 5-HT in self stimulation.

摘要

5-羟色胺（5-HT，血清素）特异性突触前再摄取抑制剂礼来110140（盐酸氟西汀）被全身注射到经过训练通过按压杠杆以获得对内侧前脑束尾部的奖赏性刺激的大鼠体内。自我刺激的速率与药物剂量成比例降低，并且这些降低可被甲基麦角新碱部分逆转。这些发现与先前表明5-HT在自我刺激中起抑制作用的报告一致。

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Effects of Lilly 110140 (flouxetine) on self-stimulation behavior in the dorsal and ventral regions of the lateral hypothalamus in the mouse.礼来110140（氟西汀）对小鼠下丘脑外侧背侧和腹侧区域自我刺激行为的影响。
Psychopharmacology (Berl). 1980;71(2):143-6. doi: 10.1007/BF00434402.
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