Effects of Lilly 110140 (flouxetine) on self-stimulation behavior in the dorsal and ventral regions of the lateral hypothalamus in the mouse.

The effects of Lilly 110141 (fluoxetine) injected IP on self-stimulation behavior triggered in the dorsal and ventral regions of the lateral hypothalamus were studied in C57BL/6 mice strain. Lilly 110140 inhibits serotonin reuptake. It depresses dorsal self-stimulation at a low dose (5 mg/kg) and improves ventral sel-stimulation at a high dose (20 mg/kg). The changes brought about by the injection of the 5 mg/kg dose support the proposed inhibitory role of serotonin on self-stimulation and also suggest that the fibers communicating with certain serotonergic neurons are localized primarily in the dorsal region of the lateral hypothalamus.