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调节性T细胞稳定性和功能的表观遗传控制：对转化医学的启示

Epigenetic Control of Regulatory T Cell Stability and Function: Implications for Translation.

作者信息

Joudi Anthony M, Reyes Flores Carla P, Singer Benjamin D

机构信息

Department of Medicine, Division of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, United States.

Canning Thoracic Institute, Northwestern University Feinberg School of Medicine, Chicago, IL, United States.

出版信息

Front Immunol. 2022 Mar 2;13:861607. doi: 10.3389/fimmu.2022.861607. eCollection 2022.

DOI:10.3389/fimmu.2022.861607
PMID:35309306
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8924620/
Abstract

FoxP3 regulatory T (Treg) cells maintain immune homeostasis, promote self-tolerance, and have an emerging role in resolving acute inflammation, providing tissue protection, and repairing tissue damage. Some data suggest that FoxP3 T cells are plastic, exhibiting susceptibility to losing their function in inflammatory cytokine-rich microenvironments and paradoxically contributing to inflammatory pathology. As a result, plasticity may represent a barrier to Treg cell immunotherapy. Here, we discuss controversies surrounding Treg cell plasticity and explore determinants of Treg cell stability in inflammatory microenvironments, focusing on epigenetic mechanisms that clinical protocols could leverage to enhance efficacy and limit toxicity of Treg cell-based therapeutics.

摘要

叉头框蛋白P3调节性T（Treg）细胞维持免疫稳态，促进自身耐受，并在解决急性炎症、提供组织保护和修复组织损伤方面发挥着越来越重要的作用。一些数据表明，FoxP3 T细胞具有可塑性，在富含炎性细胞因子的微环境中易失去其功能，并且反常地促成炎症病理过程。因此，可塑性可能是Treg细胞免疫治疗的一个障碍。在此，我们讨论围绕Treg细胞可塑性的争议，并探讨炎性微环境中Treg细胞稳定性的决定因素，重点关注临床方案可利用以提高基于Treg细胞疗法的疗效并限制其毒性的表观遗传机制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3665/8924620/15ab1eabb26d/fimmu-13-861607-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3665/8924620/e2edea684a32/fimmu-13-861607-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3665/8924620/2c708af60d7f/fimmu-13-861607-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3665/8924620/15ab1eabb26d/fimmu-13-861607-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3665/8924620/e2edea684a32/fimmu-13-861607-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3665/8924620/2c708af60d7f/fimmu-13-861607-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3665/8924620/15ab1eabb26d/fimmu-13-861607-g003.jpg

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