Wilks J W
Prostaglandins. 1977 Jan;13(1):161-70. doi: 10.1016/0090-6980(77)90053-3.
The naturally-occurring metabolite of prostaglandin F2alpha, 15-keto prostaglandin F2alpha (15-keto PGF2alpha), elicited rapid and sustained declines in serum progesterone concentrations when administered to rhesus monkeys beginning on day 22 of normal menstrual cycles. Evidence for luteolysis of a more convincing nature was obtained in studies where a single dose of 15-keto PGF2alpha was given on day 20 of ovulatory menstrual cycles in which intramuscular injections of hCG were also given on days 18-20; serum progesterone concentrations fell precipitously in monkeys within 24 hours following intramuscular administration of 15-keto PGF2alpha. However, corpus luteum function was impaired in only 4 of 11 early pregnant monkeys when 15-keto PGF2alpha was administered on days 30 and 31 from the last menses, a time when the ovary is essential for the maintenance of pregnancy. Gestation failed in 2 additional monkeys 32 and 60 days after treatment with 15-keto PGF2alpha, but progressed in an apparently normal manner in the remaining 5 animals. Two pregnant monkeys treated with 15-keto PGF2alpha on day 42 from the last menstrual period, a time when the ovary is no longer required for gestation, continued their pregnancies uneventfully. Corpus luteum function was not impaired in 9 control monkeys which received injections of vehicle or hCG at appropriate times during the menstrual cycle or pregnancy.
前列腺素F2α的天然代谢产物15-酮基前列腺素F2α（15-keto PGF2α），在正常月经周期的第22天开始给恒河猴给药时，会引起血清孕酮浓度迅速且持续下降。在排卵性月经周期的第20天给予单剂量15-酮基PGF2α的研究中，获得了更具说服力的黄体溶解证据，在这些研究中，在第18 - 20天还进行了肌肉注射人绒毛膜促性腺激素；肌肉注射15-酮基PGF2α后24小时内，猴子的血清孕酮浓度急剧下降。然而，当在末次月经后的第30天和第31天给予15-酮基PGF2α时，11只早孕猴子中只有4只的黄体功能受损，此时卵巢对维持妊娠至关重要。另外2只猴子在接受15-酮基PGF2α治疗后32天和60天妊娠失败，但其余5只动物的妊娠以明显正常的方式进展。在末次月经后的第42天给予15-酮基PGF2α治疗的2只妊娠猴子，此时妊娠不再需要卵巢，其妊娠继续顺利进行。9只对照猴子在月经周期或妊娠期间的适当时间接受了赋形剂或人绒毛膜促性腺激素注射，其黄体功能未受损。
