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Harnessing the power of ionising radiation to enhance cancer immunotherapy.

作者信息

Pang Kai, Zhang Zhongtao

机构信息

Department of General Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing, China.

出版信息

Clin Transl Med. 2025 Apr;15(4):e70307. doi: 10.1002/ctm2.70307.

DOI:10.1002/ctm2.70307
PMID:40268522
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12017892/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1be2/12017892/af66aea8cf8f/CTM2-15-e70307-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1be2/12017892/e456684f25a4/CTM2-15-e70307-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1be2/12017892/af66aea8cf8f/CTM2-15-e70307-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1be2/12017892/e456684f25a4/CTM2-15-e70307-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1be2/12017892/af66aea8cf8f/CTM2-15-e70307-g002.jpg

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本文引用的文献

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Neoadjuvant chemoradiation with or without PD-1 blockade in locally advanced rectal cancer: a randomized phase 2 trial.局部晚期直肠癌新辅助放化疗联合或不联合PD-1阻断：一项随机2期试验
Nat Med. 2025 Feb;31(2):449-456. doi: 10.1038/s41591-024-03360-5. Epub 2025 Jan 6.
2
The evolving landscape of tissue-agnostic therapies in precision oncology.精准肿瘤学中组织不可知治疗方法的不断发展。
CA Cancer J Clin. 2024 Sep-Oct;74(5):433-452. doi: 10.3322/caac.21844. Epub 2024 May 30.
3
Emerging evidence for adapting radiotherapy to immunotherapy.
新兴证据表明放疗与免疫疗法相结合具有优势。
Nat Rev Clin Oncol. 2023 Aug;20(8):543-557. doi: 10.1038/s41571-023-00782-x. Epub 2023 Jun 6.
4
PD-1 Blockade in Mismatch Repair-Deficient, Locally Advanced Rectal Cancer.PD-1 阻断在错配修复缺陷、局部晚期直肠癌中的应用。
N Engl J Med. 2022 Jun 23;386(25):2363-2376. doi: 10.1056/NEJMoa2201445. Epub 2022 Jun 5.
5
Five-Year Survival Outcomes From the PACIFIC Trial: Durvalumab After Chemoradiotherapy in Stage III Non-Small-Cell Lung Cancer.PACIFIC试验的五年生存结果：III期非小细胞肺癌放化疗后使用度伐利尤单抗治疗
J Clin Oncol. 2022 Apr 20;40(12):1301-1311. doi: 10.1200/JCO.21.01308. Epub 2022 Feb 2.
6
ZBP1-MLKL necroptotic signaling potentiates radiation-induced antitumor immunity via intratumoral STING pathway activation.ZBP1-MLKL坏死性凋亡信号通过肿瘤内STING通路激活增强辐射诱导的抗肿瘤免疫。
Sci Adv. 2021 Oct 8;7(41):eabf6290. doi: 10.1126/sciadv.abf6290. Epub 2021 Oct 6.
7
Neoadjuvant durvalumab with or without stereotactic body radiotherapy in patients with early-stage non-small-cell lung cancer: a single-centre, randomised phase 2 trial.早期非小细胞肺癌患者新辅助度伐利尤单抗联合或不联合立体定向放疗的单中心随机 2 期临床试验。
Lancet Oncol. 2021 Jun;22(6):824-835. doi: 10.1016/S1470-2045(21)00149-2. Epub 2021 May 18.
8
Neoadjuvant immunotherapy leads to pathological responses in MMR-proficient and MMR-deficient early-stage colon cancers.新辅助免疫治疗导致 MMR 功能正常和 MMR 缺陷的早期结肠癌发生病理应答。
Nat Med. 2020 Apr;26(4):566-576. doi: 10.1038/s41591-020-0805-8. Epub 2020 Apr 6.
9
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Int J Radiat Oncol Biol Phys. 2017 Dec 1;99(5):1216-1224. doi: 10.1016/j.ijrobp.2017.07.004.