Lange S, Lönnroth I, Palm A, Hydén H
Biochem Biophys Res Commun. 1985 Aug 15;130(3):1032-6. doi: 10.1016/0006-291x(85)91719-x.
Intestinal challenge with cholera toxin induces the synthesis of a hormone-like protein which counteracts intestinal hypersecretion. This study shows that the protein also inhibits GABA transport across the plasma membrane of Deiters' cells in rabbits. The inhibitory action of the protein was dose dependent, and 10(3) times more potent than met 5-enkephalin, hitherto the most effective known inhibitor of GABA transport in vitro. The influence of the protein on the plasma membrane was reversible, and did not affect either postsynaptic binding or uptake of GABA.
用霍乱毒素进行肠道刺激可诱导一种类似激素的蛋白质的合成，该蛋白质可对抗肠道分泌过多。本研究表明，该蛋白质还可抑制家兔Dieters细胞的质膜上γ-氨基丁酸（GABA）的转运。该蛋白质的抑制作用呈剂量依赖性，其效力比甲硫氨酸脑啡肽高1000倍，甲硫氨酸脑啡肽是迄今为止已知的体外最有效的GABA转运抑制剂。该蛋白质对质膜的影响是可逆的，并且不影响GABA的突触后结合或摄取。
