关于Dieters神经元质膜上存在甲硫氨酸脑啡肽受体及其对γ-氨基丁酸转运的调节作用。
On the presence of met 5-enkephalin receptors on the plasma membrane of Deiters' neurons and their modulation of GABA transport.
作者信息
Cupello A, Hydén H
出版信息
J Neurosci Res. 1981;6(5):579-83. doi: 10.1002/jnr.490060504.
PMID:6275091
Abstract
Met 5-enkephalin blocks the active transport of GABA across plasma membranes of rabbit Deiters' neurons prepared by microdissection. Such an effect is receptor-mediated, being reversed by the antagonist Naloxone. This result shows that Deiters' neurons bear enkephalin receptors, and suggests a hypothesis on the mechanism of enkephalin-mediated neuronal inhibition.
摘要
甲硫氨酸脑啡肽可阻断经显微解剖制备的家兔代特氏神经元质膜上γ-氨基丁酸（GABA）的主动转运。这种作用是由受体介导的，可被拮抗剂纳洛酮逆转。这一结果表明代特氏神经元存在脑啡肽受体，并提出了一个关于脑啡肽介导神经元抑制机制的假说。
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