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2
A strain-transcending anti-AMA1 human monoclonal antibody neutralizes malaria parasites independent of direct RON2L receptor blockade.一种超越菌株的抗AMA1人单克隆抗体可中和疟原虫，且不依赖于直接阻断RON2L受体。
Cell Rep Med. 2025 Mar 18;6(3):101985. doi: 10.1016/j.xcrm.2025.101985. Epub 2025 Feb 27.
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Antibodies to polymorphic invasion-inhibitory and non-Inhibitory epitopes of Plasmodium falciparum apical membrane antigen 1 in human malaria.人疟疾中对恶性疟原虫顶膜抗原 1 多态性入侵抑制和非抑制表位的抗体。
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Limited antigenic diversity of Plasmodium falciparum apical membrane antigen 1 supports the development of effective multi-allele vaccines.恶性疟原虫顶端膜抗原1有限的抗原多样性支持有效多等位基因疫苗的开发。
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本文引用的文献

1
A strain-transcending anti-AMA1 human monoclonal antibody neutralizes malaria parasites independent of direct RON2L receptor blockade.一种超越菌株的抗AMA1人单克隆抗体可中和疟原虫，且不依赖于直接阻断RON2L受体。
Cell Rep Med. 2025 Mar 18;6(3):101985. doi: 10.1016/j.xcrm.2025.101985. Epub 2025 Feb 27.
2
Subcutaneous Administration of a Monoclonal Antibody to Prevent Malaria.皮下注射单克隆抗体预防疟疾。
N Engl J Med. 2024 May 2;390(17):1549-1559. doi: 10.1056/NEJMoa2312775. Epub 2024 Apr 26.
3
Safety and efficacy of malaria vaccine candidate R21/Matrix-M in African children: a multicentre, double-blind, randomised, phase 3 trial.疟疾疫苗候选物 R21/Matrix-M 在非洲儿童中的安全性和有效性：一项多中心、双盲、随机、3 期临床试验。
Lancet. 2024 Feb 10;403(10426):533-544. doi: 10.1016/S0140-6736(23)02511-4. Epub 2024 Feb 1.
4
Structure-based design of a strain transcending AMA1-RON2L malaria vaccine.基于结构的抗疟 AMA1-RON2L 疫苗应变超越设计。
Nat Commun. 2023 Sep 2;14(1):5345. doi: 10.1038/s41467-023-40878-7.
5
Monoclonal antibodies for malaria prevention.疟疾预防用单克隆抗体。
Mol Ther. 2022 May 4;30(5):1810-1821. doi: 10.1016/j.ymthe.2022.04.001. Epub 2022 Apr 5.
6
Heterotypic interactions drive antibody synergy against a malaria vaccine candidate.异型相互作用驱动针对一种疟疾疫苗候选物的抗体协同作用。
Nat Commun. 2022 Feb 17;13(1):933. doi: 10.1038/s41467-022-28601-4.
7
A malaria vaccine protects monkeys against virulent infection.一种疟疾疫苗可保护猴子免受致命感染。
NPJ Vaccines. 2017;2. doi: 10.1038/s41541-017-0015-7. Epub 2017 May 22.
8
Characterization of a novel inhibitory human monoclonal antibody directed against Plasmodium falciparum Apical Membrane Antigen 1.鉴定一种针对恶性疟原虫顶膜抗原 1 的新型人源单克隆抗体的抑制特性。
Sci Rep. 2016 Dec 21;6:39462. doi: 10.1038/srep39462.
9
Apical membrane antigen 1 plays a central role in erythrocyte invasion by Plasmodium species.顶端膜抗原1在疟原虫对红细胞的入侵过程中起核心作用。
Mol Microbiol. 2000 Nov;38(4):706-18. doi: 10.1046/j.1365-2958.2000.02175.x.

携手抗击疟疾：通过异型抗体相互作用实现更强联合。

Holding hands to halt malaria: stronger together through heterotypic antibody interactions.

作者信息

Bunnik Evelien M, Bol Sebastiaan, Ippolito Gregory C

机构信息

Department of Microbiology, Immunology, and Molecular Genetics, Long School of Medicine, The University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.

Department of Microbiology, Immunology, and Molecular Genetics, Long School of Medicine, The University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.

出版信息

Trends Parasitol. 2025 May;41(5):337-338. doi: 10.1016/j.pt.2025.04.004. Epub 2025 Apr 22.

DOI:10.1016/j.pt.2025.04.004
PMID:40268600
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12064373/
Abstract

Erythrocyte invasion by the malaria-causing parasite Plasmodium falciparum can be inhibited by antibodies against apical membrane antigen 1 (AMA1). Patel et al. identified two human anti-AMA1 monoclonal antibodies, one of which has strain-transcending neutralizing activity. Lateral interactions between the two antibodies improved their binding kinetics and inhibitory activity.

摘要

导致疟疾的恶性疟原虫对红细胞的入侵可被抗顶端膜抗原1（AMA1）的抗体所抑制。帕特尔等人鉴定出两种人类抗AMA1单克隆抗体，其中一种具有跨株中和活性。这两种抗体之间的侧向相互作用改善了它们的结合动力学和抑制活性。