Hassanpour Ehsan, Nasehi Mahsa, Meymandinezhad Amir, Witthauer Lilian
Department of Diabetes, Endocrinology, Nutritional Medicine and Metabolism, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Diabetes Center Berne, Bern, Switzerland.
Sci Rep. 2025 Apr 23;15(1):14200. doi: 10.1038/s41598-025-99367-0.
High-precision polarimetry is crucial for sensing and imaging applications, particularly for glucose monitoring within the physiological range of 50 to 400 mg/dl. Traditional approaches often rely on polarisation modulation using magneto-optic or liquid crystal modulators, which require high voltages or currents, limiting their practicality for wearable or implantable devices. In this work, we propose a polarisation-switching technique that alternates between two discrete polarisation states, offering a low-power alternative with miniaturisation potential. Using this method, we achieved a Mean Absolute Relative Difference of 7.7% and a Standard Error of Prediction of 9.6 mg/dl across the physiological glucose range, comparable to commercial continuous glucose monitors. Our approach demonstrates a limit of detection of approximately 40 mg/dl, with measurements performed in phosphate-buffered saline spiked with glucose. This work establishes polarisation switching as a viable alternative for glucose sensing, providing a foundation for future development of wearable and implantable glucose monitoring systems. By eliminating power-intensive components, our approach addresses key limitations of traditional polarimetric methods, paving the way for more accessible and energy-efficient diabetes management technologies.
高精度偏振测量对于传感和成像应用至关重要，特别是对于50至400mg/dl生理范围内的葡萄糖监测。传统方法通常依赖于使用磁光或液晶调制器的偏振调制，这需要高电压或电流，限制了它们在可穿戴或植入式设备中的实用性。在这项工作中，我们提出了一种偏振切换技术，该技术在两个离散偏振态之间交替，提供了一种具有小型化潜力的低功耗替代方案。使用这种方法，我们在整个生理葡萄糖范围内实现了7.7%的平均绝对相对差异和9.6mg/dl的预测标准误差，与商业连续葡萄糖监测仪相当。我们的方法在添加了葡萄糖的磷酸盐缓冲盐水中进行测量，显示出约40mg/dl的检测限。这项工作将偏振切换确立为葡萄糖传感的可行替代方案，为可穿戴和植入式葡萄糖监测系统的未来发展奠定了基础。通过消除高功率组件，我们的方法解决了传统偏振测量方法的关键限制，为更易于使用和节能的糖尿病管理技术铺平了道路。
