Usmani Sharjeel, Al Riyami Khulood, Jain Anjali, Niaz Zahida, Sayani Raza, Naumani Shah P
Department of Radiology and Nuclear Medicine, Sultan Qaboos Comprehensive Cancer Care and Research center (SQCCCRC), Muscat Oman.
Department of Pathology, Sultan Qaboos Comprehensive Cancer Care and Research center (SQCCCRC), Muscat Oman.
J Pak Med Assoc. 2025 Apr;75(4):669-670. doi: 10.47391/JPMA.25-32.
68Ga-PMSA PET imaging has revolutionized both diagnosis and radioligand therapy selection in patients with metastatic prostate cancer. We report the case of a 63-year-old man with prostate adenocarcinoma who underwent radical prostatectomy followed by radiation therapy and ADT. Found to have rising PSA levels and referred for 68Ga- PSMA PET/CT for restaging. 68Ga-PSMA PET/CT showed multiple suspicious 68Ga-PSMA PSMA avid mediastinal lymph nodes and an avid lesion in the right lower anterior abdominal wall; suspicious for metastasis. Ultrasonography guided biopsy showed metastatic prostate adenocarcinoma. In our cases, 68Ga-PSMA PET/CT identified the unexpected metastatic site which leads to change patient management and potentially improving patient outcome.
68Ga-前列腺特异性膜抗原（PMSA）正电子发射断层扫描（PET）成像彻底改变了转移性前列腺癌患者的诊断和放射性配体治疗选择。我们报告了一例63岁前列腺腺癌男性患者的病例，该患者接受了根治性前列腺切除术，随后进行了放射治疗和雄激素剥夺治疗（ADT）。发现其前列腺特异性抗原（PSA）水平升高，并转诊进行68Ga-PMSA PET/CT重新分期。68Ga-PMSA PET/CT显示多个可疑的68Ga-PMSA摄取的纵隔淋巴结以及右下前腹壁的一个摄取病灶；怀疑为转移灶。超声引导下活检显示为转移性前列腺腺癌。在我们的病例中，68Ga-PMSA PET/CT识别出意外的转移部位，这导致了患者治疗方案的改变，并有可能改善患者的预后。
