Ploidy measurements by high-resolution cytometry.

Technology has made DNA ploidy assessment a clinically and economically feasible procedure, 30 years after its clinical potential was established. This paper reviews the history of ploidy measurements, DNA cytophotometry, DNA interpretation and the prognostic value of nuclear DNA analysis in various anatomic sites. Emphasis is placed on static high-resolution cytometry, not flow cytometric methods, with a description given of the systems for rapid DNA cytometry developed as part of the TICAS Project at the University of Chicago.