Sinclair J D, Gribble P A
Alcohol. 1985 Jul-Aug;2(4):627-30. doi: 10.1016/0741-8329(85)90091-6.
Long-Evans male rats were given 7 weeks of choice between 10% ethanol and water and then were divided into 6 matched groups, 3 of which were then deprived of alcohol for 6 days. Subcutaneous cyanamide injections (10 mg/kg, 3 times daily, for 4 days) during alcohol deprivation produced a long lasting, significant increase in subsequent alcohol selection, over and above the increase produced by alcohol deprivation alone. The same injections given to a group not deprived of alcohol caused a significant suppression of alcohol drinking during the treatment and had disappeared 4 days after the last injection. Thereafter the drinking remained at the control level and did not rise to that of the group given the injections during deprivation. The groups did not differ in their subsequent selection of saline solutions.
将Long-Evans雄性大鼠置于10%乙醇和水之间进行7周的选择，然后分为6个匹配组，其中3组随后戒酒6天。在戒酒期间皮下注射氨甲酰（10毫克/千克，每日3次，共4天），与仅戒酒所产生的增加相比，随后的酒精选择有长期显著增加。对未戒酒的一组给予相同注射，在治疗期间导致酒精摄入量显著减少，且在最后一次注射后4天消失。此后，饮酒量保持在对照水平，未升至在戒酒期间接受注射组的水平。这些组在随后对盐溶液的选择上没有差异。
