Jiang Min, Li Hongmei, Zhang Qiong, Xu Tongtong, Huang Le, Zhang Jinghong, Yu Huiqing, Zhang Junhui
Department of Geriatric Oncology and Department of Palliative Care, Chongqing University Cancer Hospital, Chongqing 400030, China.
Department of Plastic Surgery, State Key Laboratory of Trauma, Burns and Combined Injury, Southwest Hospital, The Third Military Medical University (Army Medical University), Chongqing 400038, China.
Genes Dis. 2024 Dec 4;12(4):101480. doi: 10.1016/j.gendis.2024.101480. eCollection 2025 Jul.
Regulator of G protein signaling 12 (RGS12) belongs to the superfamily of RGS proteins defined by a conserved RGS domain that canonically binds and deactivates heterotrimeric G-proteins. As the largest family member, RGS12 is widely expressed in many cells and tissues. In the past few decades, it has been found that RGS12 affects the activity of various cells in the human body, participates in many physiological and pathological processes, and plays an important role in the pathogenesis of many diseases. Here, we set out to comprehensively review the role of RGS12 in human diseases and its mechanisms, highlighting the possibility of RGS12 as a therapeutic target for the treatment of human diseases.
G蛋白信号调节因子12（RGS12）属于RGS蛋白超家族，该家族由一个保守的RGS结构域定义，该结构域通常结合并失活异三聚体G蛋白。作为最大的家族成员，RGS12在许多细胞和组织中广泛表达。在过去几十年中，人们发现RGS12影响人体各种细胞的活性，参与许多生理和病理过程，并在许多疾病的发病机制中发挥重要作用。在此，我们着手全面综述RGS12在人类疾病中的作用及其机制，强调RGS12作为人类疾病治疗靶点的可能性。
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