抑郁症患者体内去甲替林及其10-羟基代谢物的血浆浓度——与异喹胍羟化代谢率的关系。
Plasma concentrations of nortriptyline and its 10-hydroxy metabolite in depressed patients--relationship to the debrisoquine hydroxylation metabolic ratio.
作者信息
Nordin C, Siwers B, Benitez J, Bertilsson L
出版信息
Br J Clin Pharmacol. 1985 Jun;19(6):832-5. doi: 10.1111/j.1365-2125.1985.tb02723.x.
Abstract
In 20 depressed patients treated with nortriptyline (NT) there was a significant relationship between the plasma concentration of NT and the debrisoquine metabolic ratio (rs = 0.77; P less than 0.01). (The debrisoquine test was performed after stopping NT treatment). This is in agreement with the hypothesis that the hydroxylations of NT and debrisoquine are mediated by similar enzymatic mechanisms. In contrast there was no significant relationship between the debrisoquine metabolic ratio and the plasma concentrations of the active metabolite 10-hydroxy-nortriptyline. In 11 of the patients the debrisoquine metabolic ratio was significantly higher during than after NT treatment. This may be due to an inhibition of the debrisoquine hydroxylation by NT.
摘要
在20例接受去甲替林（NT）治疗的抑郁症患者中，NT的血浆浓度与异喹胍代谢率之间存在显著相关性（rs = 0.77；P<0.01）。（异喹胍试验在停止NT治疗后进行）。这与NT和异喹胍的羟化由相似酶促机制介导的假说相符。相比之下，异喹胍代谢率与活性代谢物10-羟基去甲替林的血浆浓度之间无显著相关性。11例患者中，异喹胍代谢率在NT治疗期间显著高于治疗后。这可能是由于NT对异喹胍羟化的抑制作用。
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