Levenson J, Simon A C, Bouthier J, Maarek B C, Safar M E
Br J Clin Pharmacol. 1985;20 Suppl 1(Suppl 1):107S-113S. doi: 10.1111/j.1365-2125.1985.tb05151.x.
By using simultaneous recording curves obtained with pulsed Doppler velocimetry and strain gauge mechanography, forearm arterial haemodynamics were studied in 26 patients with mild to moderate essential hypertension. Fifteen patients received a single oral dose of nicardipine 40 mg, and 11 patients were treated with nicardipine 30 mg three times daily for 3 months. In both groups of patients there was a similar and significant (P less than 0.001) reduction in mean, systolic, and diastolic pressures. There was a slight increase in heart rate (P less than 0.05) after the single dose, but no change after 3 months of treatment. The diameter, blood velocity, and blood flow of the brachial artery increased significantly in both treatment groups. The decrease in forearm vascular resistance was significant for both treatment groups. Brachial artery compliance increased (P less than 0.01) and characteristic impedance decreased (P less than 0.01) after both single-dose and long-term therapy with nicardipine. In patients who received nicardipine for 3 months, there were close correlations between the baseline serum calcium level and the percent change in vascular resistance (r = -0.73, P less than 0.01), blood flow (r = 0.89, P less than 0.001), and blood velocity (r = 0.91. P less than 0.001) of the forearm. No correlation was found between the baseline serum calcium and the change in arterial pressure. This study provided evidence that the blood-pressure-lowering effect of nicardipine was accompanied by a direct vasodilatory action in the small and large arteries of the forearm. An increase in peripheral blood flow with concomitant improvement of arterial compliance are the consequences of these arterial actions.
通过使用脉冲多普勒测速法和应变仪机械记录法获得的同步记录曲线，对26例轻度至中度原发性高血压患者的前臂动脉血流动力学进行了研究。15例患者口服单次剂量的尼卡地平40mg，11例患者每日3次服用尼卡地平30mg，持续3个月。两组患者的平均压、收缩压和舒张压均有相似且显著（P<0.001）的降低。单次给药后心率略有增加（P<0.05），但治疗3个月后无变化。两个治疗组的肱动脉直径、血流速度和血流量均显著增加。两个治疗组的前臂血管阻力均显著降低。尼卡地平单次给药和长期治疗后，肱动脉顺应性增加（P<0.01），特性阻抗降低（P<0.01）。在接受尼卡地平治疗3个月的患者中，基线血清钙水平与前臂血管阻力变化百分比（r = -0.73，P<0.01）、血流量（r = 0.89，P<0.001）和血流速度（r = 0.91，P<0.001）之间存在密切相关性。未发现基线血清钙与动脉压变化之间存在相关性。本研究提供了证据，表明尼卡地平的降压作用伴随着在前臂小动脉和大动脉中的直接血管舒张作用。外周血流量增加以及动脉顺应性随之改善是这些动脉作用的结果。
