VO(乙酰丙酮)与溶菌酶在37°C反应时形成混合价态笼状多氧化钒酸盐。
Formation of Mixed-Valence Cage-Like Polyoxidovanadates at 37°C Upon Reaction of VO(acetylacetonato) With Lysozyme.
作者信息
Tito Gabriella, Ferraro Giarita, Garribba Eugenio, Merlino Antonello
机构信息
Department of Chemical Sciences, University of Naples Federico II, Complesso Universitario di Monte Sant'Angelo, Via Cintia, Napoli, I-80126, Italy.
Dipartimento di Medicina, Chirurgia e Farmacia, Università di Sassari, Viale San Pietro, Sassari, I-07100, Italy.
出版信息
Chemistry. 2025 Jun 6;31(32):e202500488. doi: 10.1002/chem.202500488. Epub 2025 May 13.
Crystals of the model protein lysozyme were grown and soaked with the potential drug VO(acetylacetonato) at 37°C. X-ray diffraction and electron paramagnetic resonance (EPR) data collected at this temperature reveal that mixed-valence cage-like polyoxidovanadate clusters are formed and covalently bind protein residue side chains at physiological temperature.
对模型蛋白溶菌酶的晶体进行培养，并于37°C下用潜在药物VO(乙酰丙酮)进行浸泡。在此温度下收集的X射线衍射和电子顺磁共振(EPR)数据表明，形成了混合价态的笼状多氧化钒酸盐簇，且在生理温度下与蛋白质残基侧链共价结合。
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