Sánchez S S, Riera A N
Steroids. 1977 Feb;29(2):215-27. doi: 10.1016/0039-128x(77)90040-x.
Glucose- 6phosphate dehydrogenase (G-6PDH) stimulation by estradiol- 17beta has been studied in oviduct and liver of Bufa arenarum. OviducalG-6PDH has been found to be stimulated by a single dose of estradiol- 17beta (100 mug/100 g body weight), the stimulation being dependent on season. Hepatic G-6PDH of females is susceptible to hormonal stimulation, without seasonal variation, while in males the enzymatic activity is not modified under the same conditions. The stimulating effect of estrogen on oviducal and hepatic G- 6PDH was inhibited by Actynomicin D. The susceptibility of G- 6PDH to estrogenic action would assure NADPH production, indispensable for the biosynthesis of lipids which are required for cell growth and for hepatic vitellogenesis.
已对阿根廷蟾蜍输卵管和肝脏中17β-雌二醇对葡萄糖-6-磷酸脱氢酶（G-6PDH）的刺激作用进行了研究。已发现单剂量的17β-雌二醇（100微克/100克体重）可刺激输卵管G-6PDH，这种刺激作用取决于季节。雌性肝脏中的G-6PDH易受激素刺激，且无季节性变化，而在相同条件下雄性的酶活性未发生改变。放线菌素D可抑制雌激素对输卵管和肝脏G-6PDH的刺激作用。G-6PDH对雌激素作用的敏感性可确保产生烟酰胺腺嘌呤二核苷酸磷酸（NADPH），这对于细胞生长和肝脏卵黄生成所需的脂质生物合成是必不可少的。
