Kaler G V
Biofizika. 1985 May-Jun;30(3):431-5.
A mathematical model is proposed for cooperative rearrangements induced by specific ligand in certain biomembrane domains. They are considered as the N-valent receptors undergoing rearrangement when n less than or equal to N ligand-binding receptor sites are occupied. The model predicts distinct sigmoidal dependence for change of some structural parameter on ligand concentration when the receptor site-ligand affinity remains constant as binding rises (positive cooperativity is absent).
提出了一个数学模型，用于描述特定配体在某些生物膜区域诱导的协同重排。它们被视为当n个（n小于或等于N）配体结合受体位点被占据时发生重排的N价受体。当受体位点与配体的亲和力在结合增加时保持恒定（不存在正协同性），该模型预测了某些结构参数的变化对配体浓度有明显的S形依赖性。
