Chirkov Iu Iu, Malatsidze M A, Sobolev A S
Nauchnye Doki Vyss Shkoly Biol Nauki. 1985(5):38-41.
The radioprotective ability of adrenaline, noradrenaline and isoproterenol in various concentrations has been studied in experiments on cultured Chinese hamster fibroblasts in vitro. Radioprotective effect of isoproterenol is pronounced at 10(-8)M concentration; adrenaline and especially noradrenaline are effective at higher concentrations. The antagonist of beta-adrenergic receptors propranolol blocks the radioprotective effect of catecholamines on cells. The beta-adrenergic mechanism of catecholamines radioprotective action on the mammals cells is under discussion.
在体外培养的中国仓鼠成纤维细胞实验中，研究了不同浓度肾上腺素、去甲肾上腺素和异丙肾上腺素的辐射防护能力。异丙肾上腺素在10(-8)M浓度时具有明显的辐射防护作用；肾上腺素尤其是去甲肾上腺素在较高浓度时有效。β-肾上腺素能受体拮抗剂普萘洛尔可阻断儿茶酚胺对细胞的辐射防护作用。儿茶酚胺对哺乳动物细胞辐射防护作用的β-肾上腺素能机制正在讨论中。
