[异丙肾上腺素对哺乳动物细胞培养的辐射防护作用的β-肾上腺素能机制]
[Beta-adrenergic mechanism of the radio-protective effect of isoproterenol in a mammalian cell culture].
作者信息
Chirkov Iu Iu, Babiĭ N I, Sobolev A S
出版信息
Radiobiologiia. 1983 Nov-Dec;23(6):819-22.
PMID:6318258
Abstract
A specific beta-agonist, isoproterenol, increased the intracellular content of cyclic AMP and decreased the radiosensitivity of Chinese hamster fibroblasts. Beta-antagonist, propranolol, blocked the manifestation of the effect of isoproterenol. Isoproterenol did not affect either the intracellular level of cyclic AMP or the radiosensitivity of B-82 cells which had no beta-adrenoreceptors.
摘要
一种特定的β-激动剂异丙肾上腺素，增加了环磷酸腺苷的细胞内含量，并降低了中国仓鼠成纤维细胞的放射敏感性。β-拮抗剂普萘洛尔阻断了异丙肾上腺素作用的表现。异丙肾上腺素对没有β-肾上腺素受体的B-82细胞的环磷酸腺苷细胞内水平或放射敏感性均无影响。
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