Noble R C, Shand J H, Christie W W
Biol Neonate. 1985;47(6):333-8. doi: 10.1159/000242136.
Incubation in vitro of sheep placental homogenates with [1-14C] oleic, linoleic and linolenic acids resulted in extensive amounts of radioactivity becoming associated with C20 and C22 polyunsaturated fatty acid products. The fatty acids of the fetal plasma displayed substantial levels of both C20 and C22 polyunsaturated fatty acids, including the n-9 eicosatrienoic fatty acid associated with essential fatty acid deficiency, but extremely low levels of linoleic and linolenic acids. A role for the placenta in the provision to the fetus of a range of C20 and C22 polyunsaturated fatty acids derived from C18 fatty acid precursors is implicated.
将绵羊胎盘匀浆与[1-¹⁴C]油酸、亚油酸和亚麻酸进行体外温育，结果导致大量放射性与C20和C22多不饱和脂肪酸产物相结合。胎儿血浆中的脂肪酸显示出C20和C22多不饱和脂肪酸的大量存在，包括与必需脂肪酸缺乏相关的n-9二十碳三烯酸，但亚油酸和亚麻酸的含量极低。这表明胎盘在为胎儿提供一系列源自C18脂肪酸前体的C20和C22多不饱和脂肪酸方面发挥了作用。
