Yuan Haitao, Qiu Yun, Mei Zijie, Liu Jiaqing, Wang Lingna, Zhang Kaiqing, Liu Huicong, Zhu Fangfang
School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, PR China.
School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, PR China.
Cancer Lett. 2025 Aug 1;624:217737. doi: 10.1016/j.canlet.2025.217737. Epub 2025 Apr 22.
Cancer stem cells (CSCs) depend on the tumor microenvironment (TME) to sustain their stem-like properties by recruiting monocytes and reprogramming them into tumor-associated macrophages (TAMs), which in turn promote tumor progression. This review explores CSC-TAM interactions, emphasizing how CSCs drive monocyte recruitment and TAM polarization. We discuss how TAMs enhance CSC stemness and niche maintenance through chemokines, cytokines, exosome-mediated miRNA transfer, direct interactions, and extracellular matrix (ECM) remodeling. Furthermore, we examine therapeutic strategies targeting TAMs, including inhibiting TAM differentiation, reprogramming TAM polarization, and leveraging immune checkpoint blockade and CAR-macrophage immunotherapy to improve cancer treatment outcomes.
癌症干细胞（CSCs）依赖肿瘤微环境（TME）来维持其干细胞样特性，它们通过招募单核细胞并将其重编程为肿瘤相关巨噬细胞（TAMs），而TAMs反过来又促进肿瘤进展。本综述探讨了CSC-TAM相互作用，重点强调了CSCs如何驱动单核细胞招募和TAM极化。我们讨论了TAMs如何通过趋化因子、细胞因子、外泌体介导的miRNA转移、直接相互作用以及细胞外基质（ECM）重塑来增强CSC干性和生态位维持。此外，我们研究了针对TAMs的治疗策略，包括抑制TAM分化、重编程TAM极化，以及利用免疫检查点阻断和CAR巨噬细胞免疫疗法来改善癌症治疗效果。
