Sewell Kelsey R, Collins Audrey M, Chappel-Farley Miranda G, Jain Shivangi, Huang Haiqing, Grove George, Kramer Arthur F, McAuley Edward, Burns Jeffrey, Hillman Charles, Vidoni Eric, Marsland Anna, Kang Chaeryon, Wan Lu, Wilckens Kristine A, Erickson Kirk I
Innovation Tower, AdventHealth Research Institute, 265 E Rollins St, Suite 2100, NeuroscienceOrlando, FL, 32804, USA.
Centre for Healthy Ageing, Health Futures Institute, Murdoch University, Murdoch, Western Australia, 6150, Australia.
Geroscience. 2025 Apr 25. doi: 10.1007/s11357-025-01665-y.
Poor sleep is associated with worse cognitive function in older adults. However, nuanced associations between sleep and cognition might be masked by the multidimensional nature of sleep which requires multiple approaches (e.g., self-report and actigraphy) to gain meaningful insight. We investigated associations of sleep with cognition and hypothesized that the most consistent association would be between self-reported sleep duration and actigraphy-measured wake after sleep onset (WASO). We utilized baseline data from the Investigating Gains in Neurocognition in an Intervention Trial of Exercise study. Cognitively unimpaired older adults (n=589, aged 65-80) completed a comprehensive cognitive assessment with generation of five domain-specific cognitive composite scores. Sleep was measured via the Pittsburgh Sleep Quality Index (PSQI) and 24-h actigraphy (GT9X Link). Greater actigraphy WASO and shorter self-reported sleep duration were associated with poorer performance in all five cognitive domains (β = -0.14 to -0.19, all p<0.05; β = 0.08-0.15, all p<0.05). Shorter actigraphy sleep duration was also associated with poorer EF/attentional control (β=0.09, p=0.020) and processing speed (β=0.10, p=0.013). Actigraphy and self-reported sleep were more strongly associated with episodic memory in older (74 years) and younger (66 years) individuals, respectively. Actigraphy-derived WASO was consistently and robustly associated with cognitive performance. Additionally, our results suggest that self-reported sleep duration provides insight into sleep behaviors related to brain health (e.g., long periods of still wakefulness), beyond actigraphy-measured sleep duration. Thus, both self-report and actigraphy measures of sleep provide critical and unique information for interpreting relationships with cognitive performance.
睡眠质量差与老年人认知功能较差有关。然而，睡眠与认知之间的细微关联可能会被睡眠的多维度性质所掩盖，这需要多种方法（如自我报告和活动记录仪）才能获得有意义的见解。我们研究了睡眠与认知之间的关联，并假设最一致的关联将存在于自我报告的睡眠时间与活动记录仪测量的睡眠后觉醒时间（WASO）之间。我们利用了“运动干预试验中神经认知增益调查”研究的基线数据。认知功能未受损的老年人（n = 589，年龄65 - 80岁）完成了一项全面的认知评估，生成了五个特定领域的认知综合得分。通过匹兹堡睡眠质量指数（PSQI）和24小时活动记录仪（GT9X Link）测量睡眠。在所有五个认知领域中，活动记录仪测量的WASO时间越长和自我报告的睡眠时间越短，与较差的认知表现相关（β = -0.14至-0.19，所有p < 0.05；β = 0.08 - 0.15，所有p < 0.05）。活动记录仪测量的睡眠时间较短也与较差的执行功能/注意力控制（β = 0.09，p = 0.020）和处理速度（β = 0.10，p = 0.013）相关。活动记录仪和自我报告的睡眠分别与年龄较大（74岁）和较年轻（66岁）个体的情景记忆更密切相关。活动记录仪得出的WASO与认知表现始终且强烈相关。此外，我们的结果表明，自我报告的睡眠时间提供了有关与大脑健康相关的睡眠行为（例如长时间静止觉醒）的见解，这超出了活动记录仪测量的睡眠时间。因此，睡眠的自我报告和活动记录仪测量都为解释与认知表现的关系提供了关键且独特的信息。
