Liu Lian, Li Qiu, Zhang Gaofu
Department of pediatrics, University-town Hospital of Chongqing Medical University, Chongqing, 400014, China.
Department of Nephrology; National Clinical Research Center for Child Health and Disorders; Ministry of Education Key Laboratory of Child Development and Disorders; China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Children's Hospital of Chongqing Medical University, Chongqing, 400014, China.
Sci Rep. 2025 Apr 24;15(1):14304. doi: 10.1038/s41598-025-96125-0.
Research indicates that minimal change disease (MCD) and focal segmental glomerulosclerosis (FSGS) may reflect varying severities of the same underlying condition, with inflammation potentially facilitating the progression from MCD to FSGS. The aim of this study was to determine the whether systemic inflammation accelerated the progression from MCD to FSGS in a mouse model of Adriamycin-induced nephrosis. In this model, systemic inflammation induced transient proteinuria without significant serum biochemical alterations or significant renal histological changes in control mice that did not develop nephrotic syndrome. In contrast, both mice with Adriamycin-induced nephrosis mice and mice with Adriamycin-induced nephrosis with systemic inflammation showed histological features of MCD at week 4 and progressive exacerbation of FSGS. However, the glomerular lesions of mice with Adriamycin-induced nephrosis in a state of systemic inflammation were more obvious than those of mice with Adriamycin-induced nephrosis. These findings suggest that systemic inflammation may hasten histological development from MCD to FSGS in this mouse model.
研究表明，微小病变性肾病（MCD）和局灶节段性肾小球硬化（FSGS）可能反映了同一潜在病症的不同严重程度，炎症可能促使疾病从MCD进展为FSGS。本研究的目的是确定在阿霉素诱导的肾病小鼠模型中，全身炎症是否会加速从MCD到FSGS的进展。在该模型中，全身炎症在未发生肾病综合征的对照小鼠中诱导出短暂蛋白尿，但血清生化指标无明显改变，肾脏组织学也无明显变化。相比之下，阿霉素诱导的肾病小鼠以及伴有全身炎症的阿霉素诱导的肾病小鼠在第4周均呈现MCD的组织学特征，且FSGS逐渐加重。然而，处于全身炎症状态的阿霉素诱导的肾病小鼠的肾小球病变比单纯阿霉素诱导的肾病小鼠更为明显。这些发现表明，在该小鼠模型中，全身炎症可能会加速从MCD到FSGS的组织学发展。
