Faiela Candido, Cambaco Olga, Boene Helena, Monnier Annelie A, Wertheim Heiman F L, Munguambe Khatia, Sevene Esperança
Department of Biological Sciences, Faculty of Science, Eduardo Mondlane University, Maputo, Mozambique.
Department of Physiological Sciences, Faculty of Medicine, Eduardo Mondlane University, Maputo, Mozambique.
Sci Rep. 2025 Apr 24;15(1):14333. doi: 10.1038/s41598-025-99030-8.
Tackling the worldwide problem of antibiotic resistance requires addressing the lack of knowledge about antibiotics and understanding the impact of resistance. This study aimed to assess healthcare professionals' (HCP) knowledge about antibiotics and antibiotic resistance and the antibiotic prescription practices for outpatients at the Manhiça District Hospital in Mozambique. This cross-sectional study assessed the knowledge and practices of 20 HCPs about antibiotic use and resistance and evaluated quality indicators of antibiotic use of 200 prescriptions. We observed that 20% of the participants incorrectly placed amoxicillin in the cephalosporin group, and 10% considered antibiotic resistance a rejection reaction by the patient's body. However, the HCPs showed Knowledge level A. Antibiotics featured in 88% of prescriptions, with an average of one antibiotic per prescription. Cotrimoxazole (30.77%) and amoxicillin (26.15%) were the most frequently prescribed antibiotics. Cotrimoxazole was more prescribed for adults (21.54%) and amoxicillin for children (17.95%). Seasonal variation was observed with an increased winter consumption of cotrimoxazole and phenoxymethylpenicillin in summer. The results revealed a high level of knowledge of HCPs about how to use and identify antibiotics. A higher frequency of broad-spectrum antibiotic prescriptions was observed with cotrimoxazole and amoxicillin being the most prescribed.
解决全球抗生素耐药性问题需要解决抗生素知识匮乏的问题，并了解耐药性的影响。本研究旨在评估莫桑比克曼希卡地区医院医护人员对抗生素和抗生素耐药性的了解，以及门诊患者的抗生素处方习惯。这项横断面研究评估了20名医护人员在抗生素使用和耐药性方面的知识与习惯，并对200份处方的抗生素使用质量指标进行了评估。我们发现，20%的参与者将阿莫西林错误地归类于头孢菌素组，10%的人认为抗生素耐药性是患者身体的排斥反应。然而，医护人员的知识水平为A。88%的处方中使用了抗生素，平均每份处方使用一种抗生素。复方新诺明（30.77%）和阿莫西林（26.15%）是最常开具的抗生素。复方新诺明在成人中开具得更多（21.54%），阿莫西林在儿童中开具得更多（17.95%）。观察到季节性变化，冬季复方新诺明的使用量增加，夏季青霉素V钾的使用量增加。结果显示，医护人员在如何使用和识别抗生素方面有较高的知识水平。观察到广谱抗生素处方的频率较高，其中复方新诺明和阿莫西林的开具频率最高。
