2000年至2016年非西班牙裔美国白人的吸烟趋势以及膀胱癌和肺-支气管癌发病率

Trends in tobacco smoking and bladder and lung-bronchial cancer rates among non-hispanic white Americans (2000-2016).

作者信息

de Andrade Diancarlos Pereira, Marques Camila Moraes, de Andrade Dayane Christina Rodrigues, Lenzi Luana, Oliveira Cláudia Sirlene, de Figueiredo Bonald Cavalcante

机构信息

Instituto de Pesquisa Pelé Pequeno Príncipe, Curitiba, 80.250-200, PR, Brazil.

Faculdades Pequeno Príncipe, Curitiba, 80.230-020, PR, Brazil.

出版信息

Arch Public Health. 2025 Apr 24;83(1):113. doi: 10.1186/s13690-025-01585-5.

DOI:10.1186/s13690-025-01585-5

PMID:40275317

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12020030/

Abstract

BACKGROUND

Cancer incidence may be linked to cumulative exposure to environmental factors, including diet, lifestyle behaviors, licit drug use (such as tobacco), and endogenous processes. Tobacco smoking (TS) is strongly associated with bladder cancer (BC) and lung-bronchial cancer (LBC). This study aimed to analyze TS, BC, and LBC rates; their correlation with sex and age; and the risk of subsequent primary cancers among BC and LBC patients in non-Hispanic white Americans (NHWAs) from 13 U.S. states.

METHODS

The percentage of smokers in 13 U.S. states from 2000 to 2016 was obtained from the Centers for Disease Control and Prevention (CDC) database. LBC and BC cases in NHWAs from 2000 to 2016 were analyzed as single primary cancers or as the first of two or more neoplasms using the United States Surveillance, Epidemiology, and End Results (SEER) database.

RESULTS

The percentage of NHWA smokers decreased in all 13 U.S. states evaluated in this study from 2000 to 2016. Over 17 years, the incidence rates of BC were 36.37 and 11.66 cases per 100,000 among men and women, respectively, while those of LBC were 68.21 and 61.53 cases per 100,000, respectively. The highest incidence rates of BC and LBC occurred in individuals over 64 years of age: BC in New York (208.9 per 100,000 men) and Massachusetts (54.33 per 100,000 women), and LBC in Kentucky (503.1 per 100,000 men; 298.5 per 100,000 women). The incidence rates of BC and LBC were correlated in most states, especially in Massachusetts, California, New Jersey, and New York. Among the 657,117 patients with LBC, 4.3% had a second type of cancer, while among the 240,461 patients with BC, 14.3% had a second type.

CONCLUSION

Despite a significant decrease in the number of smokers in the United States between 2000 and 2016, the incidence of BC in men and LBC in women has not followed a similar decline. The odds ratio of a patient diagnosed with primary BC developing a second neoplasm is 3.3 times greater than that of a patient diagnosed with primary LBC.

摘要

背景

癌症发病率可能与环境因素的累积暴露有关，这些环境因素包括饮食、生活方式行为、合法药物使用（如烟草）以及内源性过程。吸烟（TS）与膀胱癌（BC）和肺支气管癌（LBC）密切相关。本研究旨在分析吸烟率、膀胱癌和肺支气管癌发病率；它们与性别和年龄的相关性；以及来自美国13个州的非西班牙裔白人（NHWAs）中膀胱癌和肺支气管癌患者后续发生原发性癌症的风险。

方法

从疾病控制与预防中心（CDC）数据库获取2000年至2016年美国13个州的吸烟者百分比。使用美国监测、流行病学和最终结果（SEER）数据库，将2000年至2016年非西班牙裔白人中的肺支气管癌和膀胱癌病例分析为单一原发性癌症或两个或更多肿瘤中的第一个。

结果

在本研究评估的所有13个美国州中，2000年至2016年非西班牙裔白人吸烟者的百分比均有所下降。在17年期间，男性和女性的膀胱癌发病率分别为每10万人36.37例和11.66例，而肺支气管癌发病率分别为每10万人68.21例和61.53例。膀胱癌和肺支气管癌的最高发病率出现在64岁以上的人群中：纽约州的男性膀胱癌发病率（每10万人208.9例）和马萨诸塞州的女性膀胱癌发病率（每10万人54.33例），以及肯塔基州的男性肺支气管癌发病率（每10万人503.1例；女性每10万人298.5例）。在大多数州，膀胱癌和肺支气管癌的发病率具有相关性，尤其是在马萨诸塞州、加利福尼亚州、新泽西州和纽约州。在657,117例肺支气管癌患者中，4.3%患有第二种癌症，而在240,461例膀胱癌患者中，14.3%患有第二种癌症。