Morikawa Satoru, Kaieda Yuta, Usuda Satoshi, Tsunoda Kazuyuki, Kanai Takanori, Nakagawa Taneaki
Department of Dentistry and Oral Surgery, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan.
Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan.
Mayo Clin Proc Innov Qual Outcomes. 2025 Apr 16;9(3):100612. doi: 10.1016/j.mayocpiqo.2025.100612. eCollection 2025 Jun.
Oral ulcers commonly occur in Behçet disease, but severe alveolar bone loss is rarely documented. We report a case where marked periodontal destruction preceded the diagnosis of suspected intestinal Behçet disease. A 21-year-old man presented with extensive palatal ulcers and severe maxillary alveolar bone loss extending to the root apices. Radiographic examination revealed localized bone destruction confined to the palatal region. Subsequent evaluation revealed intestinal lesions characteristic of Behçet disease. A combination of systemic medications (prednisolone, mesalazine, and infliximab) and periodontal care stabilized both oral and intestinal conditions. This case highlights that severe alveolar bone destruction can manifest as a complication of intestinal Behçet disease, underscoring the importance of thorough oral examinations and integrated medical-dental care.
口腔溃疡在白塞病中较为常见,但严重的牙槽骨丧失鲜有文献记载。我们报告一例病例,在疑似肠道白塞病诊断之前出现了明显的牙周破坏。一名21岁男性患者出现广泛的腭部溃疡和严重的上颌牙槽骨丧失,病变延伸至根尖。影像学检查显示局限于腭部区域的骨质破坏。后续评估发现了白塞病的肠道病变特征。全身药物治疗(泼尼松龙、美沙拉嗪和英夫利昔单抗)与牙周护理相结合使口腔和肠道状况均得到稳定。该病例突出表明严重的牙槽骨破坏可表现为肠道白塞病的一种并发症,强调了全面口腔检查和综合医疗-牙科护理的重要性。