Mitchell I J, Jackson A, Sambrook M A, Crossman A R
Brain Res. 1985 Jul 29;339(2):346-50. doi: 10.1016/0006-8993(85)90102-7.
The autoradiographic 2-deoxyglucose uptake technique was used to visualise local cerebral metabolic activity in the monkey in recently developed models of chorea and hemiballismus. Unilateral dyskinesia was induced by injection of a gamma-aminobutyric acid antagonist into the corpus striatum (in the case of chorea) or subthalamic nucleus (in the case of hemiballismus). Patterns of 2-deoxyglucose uptake suggest that during both forms of experimental dyskinesia the subthalamic nucleus and its projection to the globus pallidus are abnormally hypoactive.
