Combined treatment with muscarinic and nicotinic cholinergic antagonists slows development of kindled seizures.
作者信息
Meyerhoff J L, Bates V E
出版信息
Brain Res. 1985 Jul 29;339(2):386-9. doi: 10.1016/0006-8993(85)90111-8.
PMID:4027634
Abstract
Rats were given daily injections of atropine, mecamylamine or both drugs in combination, 1 h prior to daily electrical amygdaloid kindling stimulation. Neither drug was effective alone, but the two drugs in combination significantly increased the latency to develop stage 5 kindled seizures.
摘要
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