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破坏蒂特尔诺菌,一位白塞病患者的罕见机会致病菌。

Tintelnotia destructans, the Rare Opportunist of a Behçet's Disease Patient.

作者信息

Gano Rita, Buendia Palacios Diana Cristina, Pinheiro Sofia

机构信息

Department of Internal Medicine, Unidade Local de Saúde Santa Maria - Hospital Pulido Valente, Lisbon, PRT.

Internal Medicine Service (Functional Unit 2.3), Unidade Local de Saúde São José - Hospital de Santo António dos Capuchos, Lisbon, PRT.

出版信息

Cureus. 2025 Mar 25;17(3):e81142. doi: 10.7759/cureus.81142. eCollection 2025 Mar.

DOI:10.7759/cureus.81142
PMID:40276447
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12019895/
Abstract

Behçet's disease is a systemic vasculitis characterized by recurrent oral and genital ulcers that can have ophthalmologic, cutaneous, neurologic, vascular, and thromboembolic manifestations. Treatment usually involves immunosuppressant medication, which leads to an increased risk of opportunistic infections. Only recently identified, is a rare fungus that can cause eye and nail infections in humans, usually refractory to standard antifungal therapy. Ocular infections are most commonly associated with ocular trauma or the use of contact lenses and may cause permanent damage without adequate treatment. We present a case of a 40-year-old man with Behçet's disease, treated with adalimumab, who developed an ocular abscess due to . This clinical case serves the purpose of alerting for an opportunistic infection caused by a newly described and rare microorganism, which is hard to identify.

摘要

白塞病是一种全身性血管炎,其特征为复发性口腔和生殖器溃疡,并可出现眼科、皮肤、神经、血管及血栓栓塞等表现。治疗通常涉及使用免疫抑制剂药物,这会增加机会性感染的风险。一种最近才被发现的罕见真菌,可导致人类眼部和指甲感染,通常对标准抗真菌治疗无效。眼部感染最常与眼外伤或使用隐形眼镜有关,若未得到充分治疗,可能会造成永久性损害。我们报告一例40岁患有白塞病的男性患者,接受阿达木单抗治疗后,因 而发生眼部脓肿。本临床病例旨在提醒注意由一种新描述的罕见微生物引起的机会性感染,这种微生物很难识别。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/907d/12019895/9c81b93b4b1a/cureus-0017-00000081142-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/907d/12019895/9c81b93b4b1a/cureus-0017-00000081142-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/907d/12019895/9c81b93b4b1a/cureus-0017-00000081142-i01.jpg

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Tintelnotia destructans, the Rare Opportunist of a Behçet's Disease Patient.破坏蒂特尔诺菌,一位白塞病患者的罕见机会致病菌。
Cureus. 2025 Mar 25;17(3):e81142. doi: 10.7759/cureus.81142. eCollection 2025 Mar.
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Keratomycosis due to Tintelnotia destructans refractory to common therapy treated successfully with systemic and local terbinafine in combination with polyhexamethylene biguanide.由毁形廷特尔孢菌引起的角膜真菌病,对常规治疗无效,采用全身及局部特比萘芬联合聚六亚甲基双胍治疗成功。
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本文引用的文献

1
Systematic literature review informing the 2022 EULAR recommendations for screening and prophylaxis of chronic and opportunistic infections in adults with autoimmune inflammatory rheumatic diseases.系统文献回顾为 2022 年 EULAR 成人自身免疫性炎症性风湿病患者慢性和机会性感染筛查和预防建议提供信息。
RMD Open. 2022 Nov;8(2). doi: 10.1136/rmdopen-2022-002726.
2
as an emerging opportunistic pathogen: First case of superinfection in herpetic keratitis.作为一种新兴的机会性致病菌:疱疹性角膜炎继发感染的首例病例。
Am J Ophthalmol Case Rep. 2020 Jun 25;19:100791. doi: 10.1016/j.ajoc.2020.100791. eCollection 2020 Sep.
3
Targeted therapies for autoimmune/idiopathic nonmalignant diseases: risk and management of opportunistic infections.
针对自身免疫/特发性非恶性疾病的靶向治疗:机会性感染的风险和管理。
Expert Opin Drug Saf. 2020 Jul;19(7):817-842. doi: 10.1080/14740338.2020.1767585. Epub 2020 May 31.
4
Contact lens associated keratitis due to .因……导致的隐形眼镜相关性角膜炎
Med Mycol Case Rep. 2019 Dec 4;27:8-10. doi: 10.1016/j.mmcr.2019.12.004. eCollection 2020 Mar.
5
Keratomycosis due to Tintelnotia destructans refractory to common therapy treated successfully with systemic and local terbinafine in combination with polyhexamethylene biguanide.由毁形廷特尔孢菌引起的角膜真菌病,对常规治疗无效,采用全身及局部特比萘芬联合聚六亚甲基双胍治疗成功。
Int Ophthalmol. 2019 Jun;39(6):1379-1385. doi: 10.1007/s10792-018-0930-2. Epub 2018 Apr 28.
6
Tintelnotia, a new genus in Phaeosphaeriaceae harbouring agents of cornea and nail infections in humans.廷特尔诺蒂亚属,座囊菌科中的一个新属,包含可引发人类角膜和指甲感染的病原体。
Mycoses. 2017 Apr;60(4):244-253. doi: 10.1111/myc.12588. Epub 2016 Dec 1.
7
Behçet's disease physiopathology: a contemporary review.白塞病的病理生理学:当代综述。
Auto Immun Highlights. 2016 Dec;7(1):4. doi: 10.1007/s13317-016-0074-1. Epub 2016 Feb 12.
8
Behcet's disease: systemic and ocular manifestations.贝赫切特病:全身表现和眼部表现。
Biomed Res Int. 2013;2013:247345. doi: 10.1155/2013/247345. Epub 2013 Oct 3.
9
Behçet's syndrome and micro-organisms.白塞综合征与微生物。
Best Pract Res Clin Rheumatol. 2011 Jun;25(3):389-406. doi: 10.1016/j.berh.2011.05.002.
10
Behçet's disease.白塞病
Best Pract Res Clin Rheumatol. 2004 Jun;18(3):291-311. doi: 10.1016/j.berh.2004.02.008.