Istanbul University, Cerrahpasa Medical School, Department of Internal Medicine, Division of Rheumatology, Istanbul, Turkey.
Best Pract Res Clin Rheumatol. 2011 Jun;25(3):389-406. doi: 10.1016/j.berh.2011.05.002.
Behçet's syndrome (BS) is a multi-systemic vasculitis of unknown aetiology. More than one mechanism seems to be operative in the pathogenesis of Behçet's syndrome, including genetic and environmental factors, causing different manifestations of the syndrome. There are several clues to the role of environmental factors and especially micro-organisms in the pathogenesis. These include clinical findings such as a decrease in the frequency of a positive pathergy reaction with surgical cleaning of the skin before the procedure, the acne-arthritis association carrying similar features to acne-associated reactive arthritis, a higher rate of tonsillectomy, cold sores, late birth order, higher number of siblings, history of travel to countries with a high incidence of BS and earlier age at first sexual intercourse. Moreover, basic research on both viruses and bacteria suggests that micro-organisms may be playing a role, possibly through heat shock proteins and T-cell hypersensitivity.
贝赫切特综合征（BS）是一种病因不明的多系统血管炎。贝赫切特综合征的发病机制似乎涉及多种机制，包括遗传和环境因素，导致该综合征的不同表现。有几个线索表明环境因素，特别是微生物在发病机制中的作用。这些包括临床发现，例如在手术清洁皮肤之前，阳性皮肤试验反应的频率降低，痤疮关节炎具有与痤疮相关的反应性关节炎相似的特征，扁桃体切除术、唇疱疹、晚出生顺序、兄弟姐妹数量较多、有前往 BS 高发国家的旅行史以及初次性交年龄较早。此外，对病毒和细菌的基础研究表明，微生物可能在发挥作用，可能是通过热休克蛋白和 T 细胞超敏反应。
