Jellestad F K, Grahnstedt S
Brain Res. 1985 Aug 12;340(2):229-34. doi: 10.1016/0006-8993(85)90918-7.
Long-term electroencephalographic (EEG) activity and neuropathological effects were studied after unilateral amygdaloid injections of kainic acid (KA) and ibotenic acid (IBO). Injections of 0.2 microgram KA caused severe epileptiform activity which lasted up to postoperative day 49. Complete losses of neuronal and glial elements appeared as cavities within the injected areas. Epileptiform activity after injections of 3.0 micrograms IBO was seen only as interictal spikes which lasted for 2-4 h after surgery. Cavities within the lesion areas were also evident in the IBO-injected rats. The results suggest that KA should be avoided as a lesion method in behavioral studies of brain functions, whereas IBO is judged to be a more suitable lesion tool, which produces only transitory and negligible epileptiform activity. However, neither KA nor IBO seems to have long-term fiber-sparing properties.
在单侧杏仁核注射 kainic 酸（KA）和鹅膏蕈氨酸（IBO）后，研究了长期脑电图（EEG）活动和神经病理学效应。注射 0.2 微克 KA 会导致严重的癫痫样活动，这种活动持续到术后第 49 天。神经元和神经胶质成分完全丧失，在注射区域内呈现为空洞。注射 3.0 微克 IBO 后的癫痫样活动仅表现为发作间期棘波，术后持续 2 - 4 小时。在注射 IBO 的大鼠中，病变区域内的空洞也很明显。结果表明，在脑功能行为研究中，应避免将 KA 作为一种损伤方法，而 IBO 被认为是一种更合适的损伤工具，它仅产生短暂且可忽略不计的癫痫样活动。然而，KA 和 IBO 似乎都没有长期的纤维保留特性。
