Cook T M, Crutcher K A
Brain Res. 1985 Jul;353(1):19-30. doi: 10.1016/0165-3806(85)90020-3.
The axons of dentate granule cells (mossy fibers) have been reported to appear in the regio superior (CA1) of the rat hippocampal formation following destruction of the pyramidal cells in the regio inferior (CA3). We undertook the present experiments to confirm this finding and to determine the requirements for this dramatic neuronal rearrangement. We found that extensive (greater than 80%) loss of CA3 cells, as well as the presence of surviving CA1 neurons within a narrow period of development (postnatal days 3-5) is necessary, however apparently not sufficient, for the appearance of CA1 mossy fibers. That the absence of normal target cells during a restricted period of mossy fiber development will lead to their association with novel targets suggests that much of the specificity of this developing connection depends on the presence of normal targets during a critical period.
据报道，在大鼠海马结构的下区域（CA3）锥体细胞被破坏后，齿状颗粒细胞的轴突（苔藓纤维）出现在上区域（CA1）。我们进行了本实验以证实这一发现，并确定这种显著的神经元重排的条件。我们发现，CA3细胞广泛（超过80%）丧失，以及在发育的狭窄时期（出生后第3 - 5天）存活的CA1神经元的存在是必要的，但显然不足以使CA1苔藓纤维出现。在苔藓纤维发育的受限时期缺乏正常靶细胞会导致它们与新靶标相关联，这表明这种发育中连接的许多特异性取决于关键时期正常靶标的存在。
