Minami T, Oomura Y, Sugimori M, Hynes M
Brain Res Bull. 1985 Jul;15(1):29-31. doi: 10.1016/0361-9230(85)90057-7.
Neuronal responses in the ventromedial hypothalamic nucleus (VMH) to mazindol (MZD) were examined by intracellular recordings in hypothalamic slices in vitro. Bath application of MZD caused depolarization of the membrane by 8.0 +/- 3.4 mV (mean +/- S.D.) associated with an increase in the input membrane resistance (23.0 +/- 5.8%) among 20% of the cells examined. Current-voltage plots, obtained simultaneously, showed the reversal potential between -80 and -90 mV. These results indicate that MZD depolarizes VMH neurons by reducing the K+ conductance, through a mechanism similar to that of glucose, and the anorectic action of MZD can be explained by its direct effects on the VMH.
通过体外下丘脑切片的细胞内记录，研究了腹内侧下丘脑核（VMH）对马吲哚（MZD）的神经元反应。在浴槽中应用MZD可使所检测细胞中的20%的细胞膜去极化8.0±3.4mV（平均值±标准差），同时输入膜电阻增加（23.0±5.8%）。同时获得的电流-电压图显示反转电位在-80至-90mV之间。这些结果表明，MZD通过类似于葡萄糖的机制降低K+电导，使VMH神经元去极化，MZD的厌食作用可以用其对VMH的直接作用来解释。
