Shiraishi T
Int J Obes. 1985;9(4):285-97.
The effects of mazindol (MZD), a non-amphetaminergic anorectic agent, on the peripheral and central control of gastric acid secretion was investigated in rats. Gastric acid secretion induced by direct application of the muscarinic cholinergic agonist, carpronium, on parietal oxyntic cells was not affected by MZD. Secretion induced by 2-deoxy-D-glucose (2DG) was markedly suppressed by intra-hypothalamic or systemic (i.v.) administration of MZD; that induced by insulin was suppressed by systemic MZD. Electrophoretic application of MZD inhibited the neuronal activity of gastric and non-gastric type glucose sensitive neurons in the lateral hypothalamus (LHA), and excited glucoreceptor neurons in the ventromedial hypothalamus (VMH). The results suggest that previous reports of feeding suppression by MZD could be explained by its effects directly on hypothalamic feeding control neurons. This is consistent with the suggestion that it might be effective in the treatment of obesity.
研究了非苯丙胺类食欲抑制剂马吲哚（MZD）对大鼠胃酸分泌的外周和中枢控制的影响。直接向壁细胞施加毒蕈碱胆碱能激动剂卡普隆铵诱导的胃酸分泌不受MZD影响。下丘脑内或全身（静脉注射）给予MZD可显著抑制2-脱氧-D-葡萄糖（2DG）诱导的分泌；全身给予MZD可抑制胰岛素诱导的分泌。电泳施加MZD可抑制下丘脑外侧区（LHA）胃型和非胃型葡萄糖敏感神经元的神经元活动，并兴奋下丘脑腹内侧核（VMH）的葡萄糖受体神经元。结果表明，先前关于MZD抑制进食的报道可以用其直接对下丘脑进食控制神经元的作用来解释。这与它可能对治疗肥胖有效这一观点一致。
