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穹窿下器的电生理学及其与下丘脑的联系——大鼠体内研究

Electrophysiology of the subfornical organ and its hypothalamic connections--an in-vivo study in the rat.

作者信息

Renaud L P, Ferguson A V, Day T A, Bourque C W, Sgro S

出版信息

Brain Res Bull. 1985 Jul;15(1):83-6. doi: 10.1016/0361-9230(85)90065-6.

DOI:10.1016/0361-9230(85)90065-6
PMID:4027707
Abstract

The connections of the subfornical organ to a defined population of hypothalamic neurons have been explored with extracellular recording methods in the rat. Electrical stimulation in the subfornical organ has a predominantly excitatory action on a majority of oxytocin and vasopressin-secreting neurosecretory neurons in the supraoptic and paraventricular nuclei. Subfornical organ stimulation also enhances the excitability of paraventricular nucleus neurons that project to the median eminence, and to the dorsomedial medulla. These observations provide initial evidence of functional connectivity of subfornical organ neurons with other hypothalamic cells that are engaged in central regulation of pituitary secretions and autonomic activities.

摘要

利用细胞外记录方法,在大鼠中探究了穹窿下器与特定下丘脑神经元群体之间的联系。穹窿下器的电刺激对视上核和室旁核中大多数分泌催产素和血管加压素的神经分泌神经元主要起兴奋作用。穹窿下器刺激还增强了投射到正中隆起和延髓背内侧的室旁核神经元的兴奋性。这些观察结果为穹窿下器神经元与其他下丘脑细胞的功能连接提供了初步证据,这些下丘脑细胞参与垂体分泌和自主活动的中枢调节。

相似文献

1
Electrophysiology of the subfornical organ and its hypothalamic connections--an in-vivo study in the rat.穹窿下器的电生理学及其与下丘脑的联系——大鼠体内研究
Brain Res Bull. 1985 Jul;15(1):83-6. doi: 10.1016/0361-9230(85)90065-6.
2
Connections from the subfornical organ to the oxytocin and vasopressin systems in the lactating rat. A study using electrical stimulations, lesions and electrophysiological recordings.泌乳大鼠穹窿下器官与催产素和血管升压素系统之间的联系。一项运用电刺激、损伤及电生理记录的研究。
Brain Res. 1995 Feb 20;672(1-2):1-13. doi: 10.1016/0006-8993(94)01278-p.
3
Inputs from the lateral hypothalamic area to subfornical organ neurons projecting to the hypothalamic supraoptic nucleus in the rat.
Nihon Juigaku Zasshi. 1986 Oct;48(5):1037-40. doi: 10.1292/jvms1939.48.1037.
4
Endothelin acts at the subfornical organ to influence the activity of putative vasopressin and oxytocin-secreting neurons.内皮素作用于穹窿下器官,以影响假定的血管加压素和催产素分泌神经元的活性。
Brain Res. 1992 Jul 17;586(1):111-6. doi: 10.1016/0006-8993(92)91378-r.
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Lateral hypothalamic area and paraventricular nucleus connections with subfornical organ neurons: an electrophysiological study in the rat.下丘脑外侧区和室旁核与穹窿下器神经元的连接:大鼠的电生理研究
Neurosci Res. 1988 Oct;6(1):45-52. doi: 10.1016/0168-0102(88)90005-3.
6
Subfornical organ and hypothalamic paraventricular nucleus connections with median preoptic nucleus neurons: an electrophysiological study in the rat.穹窿下器官和下丘脑室旁核与视前正中核神经元的连接:大鼠的电生理研究
Exp Brain Res. 1987;68(3):579-85. doi: 10.1007/BF00249800.
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The A1 noradrenergic region enhances the responsivity of hypothalamic paraventricular neurohypophyseal neurons to inputs from the subfornical organ in the rat.
Exp Brain Res. 1987;68(3):586-92. doi: 10.1007/BF00249801.
8
Angiotensin II may mediate excitatory neurotransmission from the subfornical organ to the hypothalamic supraoptic nucleus: an anatomical and electrophysiological study in the rat.
Brain Res. 1989 May 15;487(1):52-61. doi: 10.1016/0006-8993(89)90939-6.
9
The median preoptic nucleus participates in the control of paraventricular vasopressin neurons by the subfornical organ in the rat.视前正中核参与大鼠穹窿下器对室旁核加压素神经元的调控。
Brain Res. 1988 Oct 4;461(2):403-6. doi: 10.1016/0006-8993(88)90277-6.
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Lateral hypothalamic region excites the activity of vasopressin neurons in the supraoptic nucleus through subfornical organ neurons.
Exp Neurol. 1987 Jul;97(1):212-8. doi: 10.1016/0014-4886(87)90296-2.

引用本文的文献

1
Effect of NMDA-induced lesion of the subfornical organ on the angiotensin II binding sites density and acetylcholinesterase or NADPH-diphorase activities in the lamina terminalis of the rat brain.N-甲基-D-天冬氨酸诱导的穹窿下器官损伤对大鼠脑终板血管器中血管紧张素II结合位点密度及乙酰胆碱酯酶或还原型辅酶II-黄递酶活性的影响
Cell Mol Neurobiol. 2001 Feb;21(1):81-90. doi: 10.1023/a:1007125413308.
2
Expression of basic fibroblast growth factor and its receptor in the rat subfornical organ.碱性成纤维细胞生长因子及其受体在大鼠穹窿下器中的表达
Neuroendocrinology. 1991 Jul;54(1):55-61. doi: 10.1159/000125851.