Frautschy S A, Gonzalez A M, Martinez Murillo R, Carceller F, Cuevas P, Baird A
Department of Molecular and Cellular Growth Biology, Whittier Institute for Diabetes and Endocrinology, La Jolla, Calif.
Neuroendocrinology. 1991 Jul;54(1):55-61. doi: 10.1159/000125851.
Basic fibroblast growth factor (FGF), its mRNA and the mRNA that encodes for its receptor have all been localized in the rat subfornical organ (SFO). Basic FGF is widely distributed throughout the SFO; it is present in neurons, in the vascular basement membrane of lateral blood vessels (but not those within the SFO) and in ependymal cells surrounding the SFO. Results of in situ hybridization show that the expression of basic FGF mRNA is detected throughout the organ. Similarly, the expression of flg, the gene for the putative basic FGF receptor, can also be detected in the SFO. The results all support the possibility that this growth factor may modulate the known physiological functions of the SFO.
碱性成纤维细胞生长因子（FGF）、其信使核糖核酸（mRNA）以及编码其受体的mRNA均已定位在大鼠穹窿下器官（SFO）中。碱性FGF广泛分布于整个SFO；它存在于神经元、外侧血管的血管基底膜（但不包括SFO内的血管）以及围绕SFO的室管膜细胞中。原位杂交结果表明，在整个器官中均可检测到碱性FGF mRNA的表达。同样，在SFO中也可检测到flg（假定的碱性FGF受体基因）的表达。这些结果均支持这种生长因子可能调节SFO已知生理功能的可能性。
