Roze Emmanuel, Dubacq Caroline, Welniarz Quentin
Sorbonne Université, INSERM, CNRS, Paris Brain Institute Institut du Cerveau, Paris, France.
Département de Neurologie, Assistance Publique - Hôpitaux de Paris, Hôpital Pitié-Salpêtrière, Paris, France.
Mov Disord. 2025 Jul;40(7):1221-1232. doi: 10.1002/mds.30199. Epub 2025 Apr 25.
The evolution of the corticospinal tract (CST) is closely linked to the development of skilled voluntary movements in mammals. The main evolutionary divergence concerns the position of the CST within the spinal cord white matter and its postsynaptic targets in the grey matter. Here, we examine the developmental steps contributing to the CST projection pattern from an evolutionary point of view. Recent studies have highlighted the molecular mechanisms involved in these processes and how they relate to the acquisition of skilled movements. Comparison of the evolution of the CST in different species offers a new perspective on manual dexterity. In particular, it adds a new level of complexity to the classic view linking the evolution of the CST and the sequential improvement of skilled hand movements from rodents to primates. © 2025 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
皮质脊髓束（CST）的进化与哺乳动物熟练随意运动的发展密切相关。主要的进化差异涉及CST在脊髓白质中的位置及其在灰质中的突触后靶点。在这里，我们从进化的角度研究促成CST投射模式的发育步骤。最近的研究突出了这些过程中涉及的分子机制以及它们与熟练运动习得的关系。不同物种间CST进化的比较为手部灵巧性提供了新视角。特别是，它为将CST的进化与从啮齿动物到灵长类动物熟练手部运动的逐步改善联系起来的经典观点增添了新的复杂层面。© 2025作者。《运动障碍》由威利期刊有限责任公司代表国际帕金森和运动障碍协会出版。
